Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

Craig Martin McKittrick, Hilary Carswell

Research output: Contribution to conferencePoster

Abstract

Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

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Stem Cells
Stroke
Graft Rejection
Pluripotent Stem Cells
Autografts
Cell- and Tissue-Based Therapy
Cause of Death
Animal Models
Clinical Trials
Therapeutics
Research

Keywords

  • ischaemic stroke
  • stem cells
  • small pluripotent stem cells

Cite this

McKittrick, C. M., & Carswell, H. (2013). Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke. Poster session presented at Uk Preclinical Stroke Symposium, Leicester, United Kingdom.
McKittrick, Craig Martin ; Carswell, Hilary. / Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke. Poster session presented at Uk Preclinical Stroke Symposium, Leicester, United Kingdom.
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title = "Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke",
abstract = "Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.",
keywords = "ischaemic stroke, stem cells, small pluripotent stem cells",
author = "McKittrick, {Craig Martin} and Hilary Carswell",
year = "2013",
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day = "27",
language = "English",
note = "Uk Preclinical Stroke Symposium : The advantages and pitfalls of using experimental stroke models ; Conference date: 27-06-2013 Through 27-06-2013",
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McKittrick, CM & Carswell, H 2013, 'Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke' Uk Preclinical Stroke Symposium, Leicester, United Kingdom, 27/06/13 - 27/06/13, .

Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke. / McKittrick, Craig Martin; Carswell, Hilary.

2013. Poster session presented at Uk Preclinical Stroke Symposium, Leicester, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

AU - McKittrick, Craig Martin

AU - Carswell, Hilary

PY - 2013/6/27

Y1 - 2013/6/27

N2 - Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

AB - Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

KW - ischaemic stroke

KW - stem cells

KW - small pluripotent stem cells

M3 - Poster

ER -

McKittrick CM, Carswell H. Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke. 2013. Poster session presented at Uk Preclinical Stroke Symposium, Leicester, United Kingdom.