Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

Craig Martin McKittrick; Hilary Carswell

Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

Craig Martin McKittrick, Hilary Carswell

Research output: Contribution to conference › Poster

Abstract

Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

Original language	English
Publication status	Published - 27 Jun 2013
Event	Uk Preclinical Stroke Symposium: The advantages and pitfalls of using experimental stroke models - University of Leicester, Leicester, United Kingdom Duration: 27 Jun 2013 → 27 Jun 2013 https://www2.le.ac.uk/departments/npb/people/cg95/uk-preclinical-stroke-symposium

Conference

Conference	Uk Preclinical Stroke Symposium
Country	United Kingdom
City	Leicester
Period	27/06/13 → 27/06/13
Internet address	https://www2.le.ac.uk/departments/npb/people/cg95/uk-preclinical-stroke-symposium

Keywords

ischaemic stroke
stem cells
small pluripotent stem cells

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Projects

1 Finished

Escalating existing relationships with Thallocell: validation of therapeutic potential of stem cells

McKittrick, C. & Carswell, H.

1/11/12 → 31/12/12

Project: Internally funded project

Cite this

McKittrick, C. M., & Carswell, H. (2013). Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke. Poster session presented at Uk Preclinical Stroke Symposium, Leicester, United Kingdom.

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AU - Carswell, Hilary

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N2 - Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

AB - Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

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KW - small pluripotent stem cells

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Y2 - 27 June 2013 through 27 June 2013

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