Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

Craig Martin McKittrick; Hilary Carswell

Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

Craig Martin McKittrick, Hilary Carswell

Research output: Contribution to conference › Poster › peer-review

Abstract

Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

Original language	English
Publication status	Published - 27 Jun 2013
Event	Uk Preclinical Stroke Symposium: The advantages and pitfalls of using experimental stroke models - University of Leicester, Leicester, United Kingdom Duration: 27 Jun 2013 → 27 Jun 2013 https://www2.le.ac.uk/departments/npb/people/cg95/uk-preclinical-stroke-symposium

Conference

Conference	Uk Preclinical Stroke Symposium
Country/Territory	United Kingdom
City	Leicester
Period	27/06/13 → 27/06/13
Internet address	https://www2.le.ac.uk/departments/npb/people/cg95/uk-preclinical-stroke-symposium

Keywords

ischaemic stroke
stem cells
small pluripotent stem cells

Escalating existing relationships with Thallocell: validation of therapeutic potential of stem cells
McKittrick, C. (Researcher) & Carswell, H. (Principal Investigator)
1/11/12 → 31/12/12
Project: Internally funded project

Cite this

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title = "Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke",

abstract = "Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.",

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note = "Uk Preclinical Stroke Symposium : The advantages and pitfalls of using experimental stroke models ; Conference date: 27-06-2013 Through 27-06-2013",

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TY - CONF

T1 - Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

AU - McKittrick, Craig Martin

AU - Carswell, Hilary

PY - 2013/6/27

Y1 - 2013/6/27

N2 - Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

AB - Available treatments for ischaemic stroke are limited despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third most common cause of death and the leading cause of major disability worldwide. Stem cells have shown great success in animal models of stroke and are currently in use in clinical trials to treat stroke patients. However, many issues remain unresolved regarding stem cell therapy including tumourigenicity and graft rejection. Here, we evaluate a novel stem cell, known as small pluripotent stem cells, which are readily available from human blood in large numbers and display typical stem cell characteristics, are not immortilised and as an autograft should circumvent graft rejection.

KW - ischaemic stroke

KW - stem cells

KW - small pluripotent stem cells

M3 - Poster

T2 - Uk Preclinical Stroke Symposium

Y2 - 27 June 2013 through 27 June 2013

ER -

Investigation of effects of a newly discovered type of blood derived stem cell in a mouse model of stroke

Abstract

Conference

Keywords

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Projects

Escalating existing relationships with Thallocell: validation of therapeutic potential of stem cells

Cite this