Investigating the role of excipients on the physical stability of directly compressed tablets

Natalie Maclean, Ibrahim Khadra, James Mann, Helen Williams, Alexander Abbott, Heather Mead, Daniel Markl

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
17 Downloads (Pure)

Abstract

Stability studies are an integral part of the drug development process for any drug product. In addition to monitoring chemical degradation, the physical stability of a drug product must also be evaluated to ensure that the drug release and performance is not affected by storage. In this study, directly compressed tablets of 16 different formulations were exposed to an accelerated stability program to quantify changes in tablet breaking force, porosity, contact angle and disintegration time. Tablets were exposed to five different storage conditions from 37∘C/30% relative humidity (RH) to 70∘C/75%RH with testing after 2 and 4 weeks of storage. Each formulation contained two different fillers (47% w/w each), a disintegrant (5% w/w) and magnesium stearate (1% w/w). The results show that tablets stored at high humidity show increases in porosity and decreases in tensile strength, particularly if they contain a highly hygroscopic filler such as microcrystalline cellulose (MCC). For tablets stored at high temperature, the most commonly affected property was the tablet wettability, measured by sessile drop contact angle measurements. These results are considered in combination with the performance-controlling disintegration mechanism (Maclean et al., 2021) to identify the critical properties which influence the performance after storage.
Original languageEnglish
Article number100106
Number of pages9
JournalInternational Journal of Pharmaceutics: X
Volume4
Issue numberDec 2022
Early online date9 Dec 2021
DOIs
Publication statusE-pub ahead of print - 9 Dec 2021

Keywords

  • physical stability
  • accelerated stability
  • sample storage
  • disintegration mechanism

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