Investigating the micro-rheology of the vitreous humor using an optically trapped local probe

Fiona Watts, Lay Ean Tan, Clive G Wilson, John M Girkin, Tassieri Manlio, Amanda J Wright

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.
LanguageEnglish
Article number015301
Number of pages7
JournalJournal of Optics
Volume16
Issue number1
DOIs
Publication statusPublished - 11 Dec 2013

Fingerprint

Rheology
rheology
beads
probes
Brownian movement
Viscoelasticity
Silicon Dioxide
Pharmaceutical Preparations
Drug products
Aging of materials
Cameras
viscoelasticity
Silica
delivery
drugs
cameras
silicon dioxide
predictions

Keywords

  • optical trapping
  • micro-rheology
  • vitreous humor

Cite this

Watts, F., Tan, L. E., Wilson, C. G., Girkin, J. M., Manlio, T., & Wright, A. J. (2013). Investigating the micro-rheology of the vitreous humor using an optically trapped local probe. Journal of Optics, 16(1), [015301]. https://doi.org/10.1088/2040-8978/16/1/015301
Watts, Fiona ; Tan, Lay Ean ; Wilson, Clive G ; Girkin, John M ; Manlio, Tassieri ; Wright, Amanda J. / Investigating the micro-rheology of the vitreous humor using an optically trapped local probe. In: Journal of Optics. 2013 ; Vol. 16, No. 1.
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Investigating the micro-rheology of the vitreous humor using an optically trapped local probe. / Watts, Fiona; Tan, Lay Ean; Wilson, Clive G; Girkin, John M; Manlio, Tassieri; Wright, Amanda J.

In: Journal of Optics, Vol. 16, No. 1, 015301, 11.12.2013.

Research output: Contribution to journalArticle

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