Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

M. T. Islam; J. Robertson; F. Tahir; A. Florence

Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

M. T. Islam, J. Robertson, F. Tahir, A. Florence

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster › peer-review

214 Downloads (Pure)

Abstract

There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.

Original language	English
Publication status	Published - 7 Sept 2016
Event	7th APS International PharmSci Conference - University of Strathclyde, Glasgow, United Kingdom Duration: 5 Sept 2016 → 7 Sept 2016 https://www.ukpharmsci.org/

Conference

Conference	7th APS International PharmSci Conference
Country/Territory	United Kingdom
City	Glasgow
Period	5/09/16 → 7/09/16
Internet address	https://www.ukpharmsci.org/

Keywords

hot melt extrusion
HPMC
copolymer
Affinisol
Plasdone
torque
pressure
e-specific

Access to Document

Islam_etal_PharmSci2016_Investigating_processing_window_of_Affinisol_and_Plasdone_S630_polymersAccepted author manuscript, 359 KB
Islam_etal_PharmSci2016_Poster_Investigation_of_the_processing_window_for_affinisolFinal published version, 982 KB

2016 AAPS Annual meeting and exposition
Islam, T. (Participant)
13 Nov 2016 → 17 Nov 2016
Activity: Presenting or Organising an Event › Participation in conference
CMAC Internal Research Day
Islam, T. (Participant)
10 Oct 2016 → 11 Oct 2016
Activity: Presenting or Organising an Event › Conference, workshop, seminar or course
7th APS International PharmSci Conference
Islam, T. (Participant)
5 Sept 2016 → 7 Sept 2016
Activity: Presenting or Organising an Event › Participation in conference

Cite this

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title = "Investigating processing window of Affinisol{\texttrademark} and Plasdone{\texttrademark} - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)",

abstract = "There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol{\texttrademark} (HPMC) and Plasdone{\texttrademark} S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol{\texttrademark} had a relatively narrow viable operating window compared with the Plasdone{\texttrademark}.",

keywords = "hot melt extrusion, HPMC, copolymer, Affinisol, Plasdone, torque, pressure, e-specific",

author = "Islam, \{M. T.\} and J. Robertson and F. Tahir and A. Florence",

year = "2016",

month = sep,

day = "7",

language = "English",

note = "7th APS International PharmSci Conference ; Conference date: 05-09-2016 Through 07-09-2016",

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Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). / Islam, M. T.; Robertson, J.; Tahir, F. et al.
2016. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

AU - Islam, M. T.

AU - Robertson, J.

AU - Tahir, F.

AU - Florence, A.

PY - 2016/9/7

Y1 - 2016/9/7

N2 - There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.

AB - There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.

KW - hot melt extrusion

KW - HPMC

KW - copolymer

KW - Affinisol

KW - Plasdone

KW - torque

KW - pressure

KW - e-specific

M3 - Poster

T2 - 7th APS International PharmSci Conference

Y2 - 5 September 2016 through 7 September 2016

ER -

Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

Abstract

Conference

Keywords

Access to Document

Fingerprint

Activities

2016 AAPS Annual meeting and exposition

CMAC Internal Research Day

7th APS International PharmSci Conference

Cite this