Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

M. T. Islam, J. Robertson, F. Tahir, A. Florence

Research output: Contribution to conferencePoster

129 Downloads (Pure)

Abstract

There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.
Original languageEnglish
Publication statusPublished - 7 Sep 2016
Event7th APS International PharmSci Conference - University of Strathclyde, Glasgow, United Kingdom
Duration: 5 Sep 20167 Sep 2016
https://www.ukpharmsci.org/

Conference

Conference7th APS International PharmSci Conference
CountryUnited Kingdom
CityGlasgow
Period5/09/167/09/16
Internet address

Keywords

  • hot melt extrusion
  • HPMC
  • copolymer
  • Affinisol
  • Plasdone
  • torque
  • pressure
  • e-specific

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  • Activities

    • 2 Participation in conference
    • 1 Participation in workshop, seminar, course

    2016 AAPS Annual meeting and exposition

    Tariq Islam (Participant)

    13 Nov 201617 Nov 2016

    Activity: Participating in or organising an event typesParticipation in conference

    CMAC Internal Research Day

    Tariq Islam (Participant)

    10 Oct 201611 Oct 2016

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    7th APS International PharmSci Conference

    Tariq Islam (Participant)

    5 Sep 20167 Sep 2016

    Activity: Participating in or organising an event typesParticipation in conference

    Cite this

    Islam, M. T., Robertson, J., Tahir, F., & Florence, A. (2016). Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.