Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

M. T. Islam, J. Robertson, F. Tahir, A. Florence

Research output: Contribution to conferencePoster

Abstract

There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.

Conference

Conference7th APS International PharmSci Conference
CountryUnited Kingdom
CityGlasgow
Period5/09/167/09/16
Internet address

Fingerprint

Extruders
Extrusion
Printing
Polymers
Processing
Dispersions
Drug products
Copolymers
Color
Degradation
Monitoring
Hot Temperature

Keywords

  • hot melt extrusion
  • HPMC
  • copolymer
  • Affinisol
  • Plasdone
  • torque
  • pressure
  • e-specific

Cite this

Islam, M. T., Robertson, J., Tahir, F., & Florence, A. (2016). Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.
Islam, M. T. ; Robertson, J. ; Tahir, F. ; Florence, A. / Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.
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abstract = "There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.",
keywords = "hot melt extrusion, HPMC, copolymer, Affinisol, Plasdone, torque, pressure, e-specific",
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note = "7th APS International PharmSci Conference ; Conference date: 05-09-2016 Through 07-09-2016",
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Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). / Islam, M. T.; Robertson, J.; Tahir, F.; Florence, A.

2016. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

AU - Islam, M. T.

AU - Robertson, J.

AU - Tahir, F.

AU - Florence, A.

PY - 2016/9/7

Y1 - 2016/9/7

N2 - There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.

AB - There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.

KW - hot melt extrusion

KW - HPMC

KW - copolymer

KW - Affinisol

KW - Plasdone

KW - torque

KW - pressure

KW - e-specific

UR - https://www.ukpharmsci.org/default.asp

M3 - Poster

ER -

Islam MT, Robertson J, Tahir F, Florence A. Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). 2016. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.