Investigating FTIR based histopathology for the diagnosis of prostate cancer

Matthew J. Baker; Ehsan Gazi; Michael D. Brown; Jonathan H. Shanks; Noel W. Clarke; Peter Gardner

doi:10.1002/jbio.200810062

Investigating FTIR based histopathology for the diagnosis of prostate cancer

Matthew J. Baker, Ehsan Gazi, Michael D. Brown, Jonathan H. Shanks, Noel W. Clarke, Peter Gardner

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Prostate cancer is the most common gender specific cancer. The current gold standard for diagnosis, histopathology, is subjective and limited by variation between different pathologists. The diagnostic problems associated with the correct grading and staging of prostate cancer (CaP) has led to an interest in the development of spectroscopic based diagnostic techniques. FTIR microspectroscopy used in combination with a Principal Component Discriminant Function Analysis (PC-DFA) was applied to investigate FTIR based histopathology for the diagnosis of CaP. In this paper we report the results of a large patient study in which FTIR has been proven to grade CaP tissue specimens to a high degree of sensitivity and specificity.

Original language	English
Pages (from-to)	104-113
Number of pages	10
Journal	Journal of Biophotonics
Volume	2
Issue number	1-2
Early online date	26 Jan 2009
DOIs	https://doi.org/10.1002/jbio.200810062
Publication status	Published - 1 Feb 2009

Keywords

FTIR
histopathology
infrared
microspectroscopy
molecular diagnosis
multivariate analysis
prostate cancer (CaP)
vibrational spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jbio.200810062

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abstract = "Prostate cancer is the most common gender specific cancer. The current gold standard for diagnosis, histopathology, is subjective and limited by variation between different pathologists. The diagnostic problems associated with the correct grading and staging of prostate cancer (CaP) has led to an interest in the development of spectroscopic based diagnostic techniques. FTIR microspectroscopy used in combination with a Principal Component Discriminant Function Analysis (PC-DFA) was applied to investigate FTIR based histopathology for the diagnosis of CaP. In this paper we report the results of a large patient study in which FTIR has been proven to grade CaP tissue specimens to a high degree of sensitivity and specificity.",

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AU - Gazi, Ehsan

AU - Brown, Michael D.

AU - Shanks, Jonathan H.

AU - Clarke, Noel W.

AU - Gardner, Peter

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KW - infrared

KW - microspectroscopy

KW - molecular diagnosis

KW - multivariate analysis

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Investigating FTIR based histopathology for the diagnosis of prostate cancer

Abstract

Keywords

UN SDGs

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