Investigating FTIR based histopathology for the diagnosis of prostate cancer

Matthew J. Baker, Ehsan Gazi, Michael D. Brown, Jonathan H. Shanks, Noel W. Clarke, Peter Gardner

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Prostate cancer is the most common gender specific cancer. The current gold standard for diagnosis, histopathology, is subjective and limited by variation between different pathologists. The diagnostic problems associated with the correct grading and staging of prostate cancer (CaP) has led to an interest in the development of spectroscopic based diagnostic techniques. FTIR microspectroscopy used in combination with a Principal Component Discriminant Function Analysis (PC-DFA) was applied to investigate FTIR based histopathology for the diagnosis of CaP. In this paper we report the results of a large patient study in which FTIR has been proven to grade CaP tissue specimens to a high degree of sensitivity and specificity.

Original languageEnglish
Pages (from-to)104-113
Number of pages10
JournalJournal of Biophotonics
Volume2
Issue number1-2
Early online date26 Jan 2009
DOIs
Publication statusPublished - 1 Feb 2009

Keywords

  • FTIR
  • histopathology
  • infrared
  • microspectroscopy
  • molecular diagnosis
  • multivariate analysis
  • prostate cancer (CaP)
  • vibrational spectroscopy

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