Introduction to biopharmaceutics measures

Hannah Batchelor, Pavel Gershkovich

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


This chapter explains why solubility, permeability, and dissolution are important in biopharmaceutics assessment. A drug needs to be in solution to undergo pharmacological processes in vitro and in vivo. There are many strategies that formulation scientists can apply to improve the solubility of a drug; there are also aspects that medicinal chemists can adapt to provide optimised drug candidates. Whilst solubility assessment is typically focussed on the drug substance; dissolution is a parameter more relevant for a formulated drug product. Membrane permeability is needed for drug distribution and elimination following absorption. Permeability of the drug across the relevant membrane is a key measurement within biopharmaceutics. Using the simple biopharmaceutics measures the permeability and likely concentration gradient (identified via the solubility) can be predicted thus the absorptive flux estimated.

Original languageEnglish
Title of host publicationBiopharmaceutics
Subtitle of host publicationFrom Fundamentals to Industrial Practice
Place of PublicationChichester, UK ; Hoboken, NJ
Number of pages8
ISBN (Electronic)9781119678366
Publication statusPublished - 1 Jan 2021


  • introduction
  • biopharmaceutics
  • measures


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  • An introduction to biopharmaceutics

    Batchelor, H., 1 Jan 2021, Biopharmaceutics: From Fundamentals to Industrial Practice. 1st ed. Chichester, UK ; Hoboken, NJ, p. 1-8 8 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

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