Research output per year
Research output per year
Hannah Batchelor, Pavel Gershkovich
Research output: Chapter in Book/Report/Conference proceeding › Chapter
This chapter explains why solubility, permeability, and dissolution are important in biopharmaceutics assessment. A drug needs to be in solution to undergo pharmacological processes in vitro and in vivo. There are many strategies that formulation scientists can apply to improve the solubility of a drug; there are also aspects that medicinal chemists can adapt to provide optimised drug candidates. Whilst solubility assessment is typically focussed on the drug substance; dissolution is a parameter more relevant for a formulated drug product. Membrane permeability is needed for drug distribution and elimination following absorption. Permeability of the drug across the relevant membrane is a key measurement within biopharmaceutics. Using the simple biopharmaceutics measures the permeability and likely concentration gradient (identified via the solubility) can be predicted thus the absorptive flux estimated.
Original language | English |
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Title of host publication | Biopharmaceutics |
Subtitle of host publication | From Fundamentals to Industrial Practice |
Place of Publication | Chichester, UK ; Hoboken, NJ |
Pages | 31-38 |
Number of pages | 8 |
Edition | 1st |
ISBN (Electronic) | 9781119678366 |
DOIs | |
Publication status | Published - 1 Jan 2021 |
Research output: Chapter in Book/Report/Conference proceeding › Chapter