Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase

Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G.N. Garcia, Viswanathan Natarajan

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Abstract

Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility.
Original languageEnglish
Pages (from-to)e16571
JournalPLoS One
Volume6
Issue number1
DOIs
Publication statusPublished - 31 Jan 2011

Keywords

  • human lung endothelial cells
  • S1P generation
  • endothelial cell motility

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    Berdyshev, E. V., Gorshkova, I., Usatyuk, P., Kalari, S., Zhao, Y., Pyne, N. J., Pyne, S., Sabbadini, R. A., Garcia, J. G. N., & Natarajan, V. (2011). Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PLoS One, 6(1), e16571. https://doi.org/10.1371/journal.pone.0016571