Interplay between distribution of live cells and growth dynamics of solid tumours

Edoardo Milotti, Vladislav Vyshemirsky, Michela Sega, Roberto Chignola

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Abstract

Experiments show that simple diffusion of nutrients and waste molecules is not sufficient to explain the typical multilayered structure of solid tumours, where an outer rim of proliferating cells surrounds a layer of quiescent but viable cells and a central necrotic region. These experiments challenge models of tumour growth based exclusively on diffusion. Here we propose a model of tumour growth that incorporates the volume dynamics and the distribution of cells within the viable cell rim. The model is suggested by in silico experiments and is validated using in vitro data. The results correlate with in vivo data as well, and the model can be used to support experimental and clinical oncology.
Original languageEnglish
Article number990
Number of pages7
JournalScientific Reports
Volume2
DOIs
Publication statusPublished - 18 Dec 2012

Keywords

  • Bayesian inference
  • computational models
  • cancer models
  • computational biophysics

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