Interplay between distribution of live cells and growth dynamics of solid tumours

Edoardo Milotti, Vladislav Vyshemirsky, Michela Sega, Roberto Chignola

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Experiments show that simple diffusion of nutrients and waste molecules is not sufficient to explain the typical multilayered structure of solid tumours, where an outer rim of proliferating cells surrounds a layer of quiescent but viable cells and a central necrotic region. These experiments challenge models of tumour growth based exclusively on diffusion. Here we propose a model of tumour growth that incorporates the volume dynamics and the distribution of cells within the viable cell rim. The model is suggested by in silico experiments and is validated using in vitro data. The results correlate with in vivo data as well, and the model can be used to support experimental and clinical oncology.
LanguageEnglish
Article number990
Number of pages7
JournalScientific Reports
Volume2
DOIs
Publication statusPublished - 18 Dec 2012

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Growth
Neoplasms
Medical Oncology
Computer Simulation
Food
In Vitro Techniques

Keywords

  • Bayesian inference
  • computational models
  • cancer models
  • computational biophysics

Cite this

Milotti, Edoardo ; Vyshemirsky, Vladislav ; Sega, Michela ; Chignola, Roberto. / Interplay between distribution of live cells and growth dynamics of solid tumours. In: Scientific Reports. 2012 ; Vol. 2.
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Interplay between distribution of live cells and growth dynamics of solid tumours. / Milotti, Edoardo; Vyshemirsky, Vladislav; Sega, Michela; Chignola, Roberto.

In: Scientific Reports, Vol. 2, 990, 18.12.2012.

Research output: Contribution to journalArticle

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AU - Milotti, Edoardo

AU - Vyshemirsky, Vladislav

AU - Sega, Michela

AU - Chignola, Roberto

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KW - computational models

KW - cancer models

KW - computational biophysics

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