Intermolecular interactions, disorder and twinning in ciprofloxacin-2,2-difluoroethanol (2/3) and ciprofloxacin-water (3/14.5)

Francesca P A Fabbiani, Jean Baptiste Arlin, Gernot Buth, Birger Dittrich, Alastair J Florence, Regine Herbst-Irmer, Heidrun Sowa

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Abstract

The antibiotic ciprofloxacin [systematic name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylate], has been crystallized as a 2:3 solvate with 2,2-difluoroethanol, 2C(17)H(18)FN(3)O(3)·3C(2)H(4)O(2), (I), and as a 3:14.5 hydrate, 3C(17)H(18)FN(3)O(3)·14.5H(2)O, (II). The structure of (I) was determined using synchrotron X-ray diffraction data and refined as a two-component nonmerohedral twin. Both structures contain several independent molecules in the asymmetric unit: (I) contains two zwitterionic ciprofloxacin molecules and three difluoroethanol solvent molecules, while (II) contains three zwitterionic ciprofloxacin molecules and a mixture of ordered and disordered water molecules. The intermolecular interactions were analysed using fingerprint plots derived from Hirshfeld surfaces, providing a detailed description of the unique environment of each independent ciprofloxacin molecule.
Original languageEnglish
Pages (from-to)o120-o124
Number of pages5
JournalActa Crystallographica Section C: Crystal Structure Communications
Volume67
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Keywords

  • anti-bacterial agents
  • ciprofloxacin
  • crystallography, X-ray
  • hydrogen bonding
  • isoquinolines
  • molecular structure
  • piperazines
  • water
  • X-ray diffraction

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