Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

M Komai-Koma, F Brombacher, P N Pushparaj, B Arendse, C McSharry, J Alexander, R Chaudhuri, A N J McKenzie, I McInnes, F Y Liew, D Xu, N.C Thompson

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Abstract

The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.
Original languageEnglish
Pages (from-to)1118-1126
Number of pages9
JournalAllergy
Volume67
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • animals
  • cell degranulation
  • anaphylaxis
  • interleukins
  • mice
  • mice, nude
  • mice, inbred BALB C
  • immunoglobulin E
  • interleukin-4
  • mice, inbred C57BL
  • histamine release
  • flow cytometry
  • mast cells

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