Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

M Komai-Koma, F Brombacher, P N Pushparaj, B Arendse, C McSharry, J Alexander, R Chaudhuri, A N J McKenzie, I McInnes, F Y Liew, D Xu, N.C Thompson

Research output: Contribution to journalArticle

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Abstract

The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.
LanguageEnglish
Pages1118-1126
Number of pages9
JournalAllergy
Volume67
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Cell Degranulation
Mast Cells
Interleukin-4
Immunoglobulin E
Antigens
Serum
Interleukin-33

Keywords

  • animals
  • cell degranulation
  • anaphylaxis
  • interleukins
  • mice
  • mice, nude
  • mice, inbred BALB C
  • immunoglobulin E
  • interleukin-4
  • mice, inbred C57BL
  • histamine release
  • flow cytometry
  • mast cells

Cite this

Komai-Koma, M ; Brombacher, F ; Pushparaj, P N ; Arendse, B ; McSharry, C ; Alexander, J ; Chaudhuri, R ; McKenzie, A N J ; McInnes, I ; Liew, F Y ; Xu, D ; Thompson, N.C. / Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. In: Allergy. 2012 ; Vol. 67, No. 9. pp. 1118-1126.
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Komai-Koma, M, Brombacher, F, Pushparaj, PN, Arendse, B, McSharry, C, Alexander, J, Chaudhuri, R, McKenzie, ANJ, McInnes, I, Liew, FY, Xu, D & Thompson, NC 2012, 'Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice' Allergy, vol. 67, no. 9, pp. 1118-1126. https://doi.org/10.1111/j.1398-9995.2012.02859.x

Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. / Komai-Koma, M; Brombacher, F; Pushparaj, P N; Arendse, B; McSharry, C; Alexander, J; Chaudhuri, R; McKenzie, A N J; McInnes, I; Liew, F Y; Xu, D; Thompson, N.C.

In: Allergy, Vol. 67, No. 9, 09.2012, p. 1118-1126.

Research output: Contribution to journalArticle

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AU - McSharry, C

AU - Alexander, J

AU - Chaudhuri, R

AU - McKenzie, A N J

AU - McInnes, I

AU - Liew, F Y

AU - Xu, D

AU - Thompson, N.C

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KW - immunoglobulin E

KW - interleukin-4

KW - mice, inbred C57BL

KW - histamine release

KW - flow cytometry

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