Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

M Komai-Koma; F Brombacher; P N Pushparaj; B Arendse; C McSharry; J Alexander; R Chaudhuri; A N J McKenzie; I McInnes; F Y Liew; D Xu; N.C Thompson

doi:10.1111/j.1398-9995.2012.02859.x

Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

M Komai-Koma, F Brombacher, P N Pushparaj, B Arendse, C McSharry, J Alexander, R Chaudhuri, A N J McKenzie, I McInnes, F Y Liew, D Xu, N.C Thompson

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Abstract

The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.

Original language	English
Pages (from-to)	1118-1126
Number of pages	9
Journal	Allergy
Volume	67
Issue number	9
DOIs	https://doi.org/10.1111/j.1398-9995.2012.02859.x
Publication status	Published - Sept 2012

Keywords

animals
cell degranulation
anaphylaxis
interleukins
mice
mice, nude
mice, inbred BALB C
immunoglobulin E
interleukin-4
mice, inbred C57BL
histamine release
flow cytometry
mast cells

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10.1111/j.1398-9995.2012.02859.x

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Komai-Koma, M., Brombacher, F., Pushparaj, P. N., Arendse, B., McSharry, C., Alexander, J., Chaudhuri, R., McKenzie, A. N. J., McInnes, I., Liew, F. Y., Xu, D., & Thompson, N. C. (2012). Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67(9), 1118-1126. https://doi.org/10.1111/j.1398-9995.2012.02859.x

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abstract = "The regulation and function of IgE in healthy individuals and in antigen-na{\"i}ve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.",

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doi = "10.1111/j.1398-9995.2012.02859.x",

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AU - Komai-Koma, M

AU - Brombacher, F

AU - Pushparaj, P N

AU - Arendse, B

AU - McSharry, C

AU - Alexander, J

AU - Chaudhuri, R

AU - McKenzie, A N J

AU - McInnes, I

AU - Liew, F Y

AU - Xu, D

AU - Thompson, N.C

PY - 2012/9

Y1 - 2012/9

N2 - The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.

AB - The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.

KW - animals

KW - cell degranulation

KW - anaphylaxis

KW - interleukins

KW - mice

KW - mice, nude

KW - mice, inbred BALB C

KW - immunoglobulin E

KW - interleukin-4

KW - mice, inbred C57BL

KW - histamine release

KW - flow cytometry

KW - mast cells

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DO - 10.1111/j.1398-9995.2012.02859.x

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VL - 67

SP - 1118

EP - 1126

JO - Allergy

JF - Allergy

IS - 9

ER -

Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

Abstract

Keywords

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