Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

J. Alexander; K.J. Bryson; X. Wei

doi:10.1016/j.micinf.2008.03.009

Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

J. Alexander, K.J. Bryson, X. Wei

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.

Original language	English
Pages (from-to)	834-839
Number of pages	5
Journal	Microbes and Infection
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/j.micinf.2008.03.009
Publication status	Published - 2008

Keywords

interleukin-18
leishmania mexicana
Th2
microbes
infection
pharmacology
medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2008.03.009

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title = "Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice",

abstract = "Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.",

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author = "J. Alexander and K.J. Bryson and X. Wei",

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T1 - Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

AU - Alexander, J.

AU - Bryson, K.J.

AU - Wei, X.

PY - 2008

Y1 - 2008

N2 - Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.

AB - Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.

KW - interleukin-18

KW - leishmania mexicana

KW - Th2

KW - microbes

KW - infection

KW - pharmacology

KW - medicine

UR - http://dx.doi.org/10.1016/j.micinf.2008.03.009

U2 - 10.1016/j.micinf.2008.03.009

DO - 10.1016/j.micinf.2008.03.009

M3 - Article

SN - 1286-4579

VL - 10

SP - 834

EP - 839

JO - Microbes and Infection

JF - Microbes and Infection

IS - 7

ER -

Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

Abstract

Keywords

UN SDGs

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