Interleukin-18 enhances a Th2 biased response and susceptibility to leishmania mexicana in BALB/c mice

J. Alexander, K.J. Bryson, X. Wei

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.
Original languageEnglish
Pages (from-to)834-839
Number of pages5
JournalMicrobes and Infection
Volume10
Issue number7
DOIs
Publication statusPublished - 2008

Keywords

  • interleukin-18
  • leishmania mexicana
  • Th2
  • microbes
  • infection
  • pharmacology
  • medicine

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