Interference-contrast optical activity: a new technique for probing the chirality of anisotropic samples and more

R. P. Cameron; U. Vogl; N. Trautmann

doi:10.1098/rsos.192201

Interference-contrast optical activity: a new technique for probing the chirality of anisotropic samples and more

R. P. Cameron, U. Vogl, N. Trautmann

Physics

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Abstract

We introduce interference-contrast optical activity (ICOA) as a new technique for probing the chirality of anisotropic samples and more. ICOA could underpin a new class of ‘chiral microscopes’, with potential applications spanning the range of chirality and beyond. Two possible versions of ICOA are described explicitly; one designed to probe the optical rotation of a transparent sample regardless of the sample’s linear birefringence (ICOA-OR) and another designed to probe gradients in the optical rotation of a transparent sample (ICOA-GOR). Simulated results for α-quartz lead us to suggest that ICOA-GOR might be applied to help monitor the growth of chiral crystals in the pharmaceutical industry. Possible directions for future research are highlighted.

Original language	English
Article number	192201
Number of pages	17
Journal	Royal Society Open Science
Volume	7
Issue number	5
DOIs	https://doi.org/10.1098/rsos.192201
Publication status	Published - 13 May 2020

Keywords

chirality
optical activity
polarization
polarimetry
microscopy
DIC

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10.1098/rsos.192201Licence: CC BY 4.0

Cameron-etal-RSOS-2020-a-new-technique-for-probing-the-chirality-of-anisotropic-samples-and-moreFinal published version, 1.28 MBLicence: CC BY 4.0

Cite this

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title = "Interference-contrast optical activity: a new technique for probing the chirality of anisotropic samples and more",

abstract = "We introduce interference-contrast optical activity (ICOA) as a new technique for probing the chirality of anisotropic samples and more. ICOA could underpin a new class of {\textquoteleft}chiral microscopes{\textquoteright}, with potential applications spanning the range of chirality and beyond. Two possible versions of ICOA are described explicitly; one designed to probe the optical rotation of a transparent sample regardless of the sample{\textquoteright}s linear birefringence (ICOA-OR) and another designed to probe gradients in the optical rotation of a transparent sample (ICOA-GOR). Simulated results for α-quartz lead us to suggest that ICOA-GOR might be applied to help monitor the growth of chiral crystals in the pharmaceutical industry. Possible directions for future research are highlighted.",

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author = "Cameron, \{R. P.\} and U. Vogl and N. Trautmann",

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language = "English",

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T1 - Interference-contrast optical activity: a new technique for probing the chirality of anisotropic samples and more

AU - Cameron, R. P.

AU - Vogl, U.

AU - Trautmann, N.

PY - 2020/5/13

Y1 - 2020/5/13

N2 - We introduce interference-contrast optical activity (ICOA) as a new technique for probing the chirality of anisotropic samples and more. ICOA could underpin a new class of ‘chiral microscopes’, with potential applications spanning the range of chirality and beyond. Two possible versions of ICOA are described explicitly; one designed to probe the optical rotation of a transparent sample regardless of the sample’s linear birefringence (ICOA-OR) and another designed to probe gradients in the optical rotation of a transparent sample (ICOA-GOR). Simulated results for α-quartz lead us to suggest that ICOA-GOR might be applied to help monitor the growth of chiral crystals in the pharmaceutical industry. Possible directions for future research are highlighted.

AB - We introduce interference-contrast optical activity (ICOA) as a new technique for probing the chirality of anisotropic samples and more. ICOA could underpin a new class of ‘chiral microscopes’, with potential applications spanning the range of chirality and beyond. Two possible versions of ICOA are described explicitly; one designed to probe the optical rotation of a transparent sample regardless of the sample’s linear birefringence (ICOA-OR) and another designed to probe gradients in the optical rotation of a transparent sample (ICOA-GOR). Simulated results for α-quartz lead us to suggest that ICOA-GOR might be applied to help monitor the growth of chiral crystals in the pharmaceutical industry. Possible directions for future research are highlighted.

KW - chirality

KW - optical activity

KW - polarization

KW - polarimetry

KW - microscopy

KW - DIC

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DO - 10.1098/rsos.192201

M3 - Article

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VL - 7

JO - Royal Society Open Science

JF - Royal Society Open Science

IS - 5

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Interference-contrast optical activity: a new technique for probing the chirality of anisotropic samples and more

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Robert Cameron, MInstP

Chiral Molecules and their Interaction with Light

Control and Applications of Structured Light and Chiral Molecules

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Interference-contrast optical activity: a new technique for probing the chirality of anisotropic samples and more

Abstract

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Robert Cameron, MInstP

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Chiral Molecules and their Interaction with Light

Control and Applications of Structured Light and Chiral Molecules

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