Interactions of prosthetic and natural vision in animals with local retinal degeneration

Henri Lorach, Xin Lei, Ludwig Galambos, Theodore Kamins, Keith Mathieson, Roopa Dalal, Philip Huie, James Harris, Daniel Palanker

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Prosthetic restoration of partial sensory loss leads to interactions between artificial and natural inputs. Ideally, the rehabilitation should allow perceptual fusion of the two modalities. Here we studied the interactions between normal and prosthetic vision in a rodent model of local retinal degeneration.  Implantation of a photovoltaic array in the subretinal space of normally sighted rats induced local degeneration of the photoreceptors above the chip, and the inner retinal neurons in this area were electrically stimulated by the photovoltaic implant powered by near-infrared (NIR) light. We studied prosthetic and natural visually evoked potentials (VEP) in response to simultaneous stimulation by NIR and visible light patterns.  We demonstrate that electrical and natural VEPs summed linearly in the visual cortex, and both responses decreased under brighter ambient light. Responses to visible light flashes increased over 3 orders of magnitude of contrast (flash/background), while for electrical stimulation the contrast range was limited to 1 order of magnitude. The maximum amplitude of the prosthetic VEP was three times lower than the maximum response to a visible flash over the same area on the retina.  Ambient light affects prosthetic responses, albeit much less than responses to visible stimuli. Prosthetic representation of contrast in the visual scene can be encoded, to a limited extent, by the appropriately calibrated stimulus intensity, which also depends on the ambient light conditions. Such calibration will be important for patients combining central prosthetic vision with natural peripheral sight, such as in age-related macular degeneration.

LanguageEnglish
Pages7444-7450
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number12
DOIs
Publication statusPublished - 1 Nov 2015

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Retinal Degeneration
Light
Evoked Potentials
Retinal Neurons
Macular Degeneration
Visual Cortex
Calibration
Electric Stimulation
Retina
Rodentia
Rehabilitation

Keywords

  • partial sensory loss
  • rehabilitation
  • retinal degeneration

Cite this

Lorach, Henri ; Lei, Xin ; Galambos, Ludwig ; Kamins, Theodore ; Mathieson, Keith ; Dalal, Roopa ; Huie, Philip ; Harris, James ; Palanker, Daniel. / Interactions of prosthetic and natural vision in animals with local retinal degeneration. In: Investigative Ophthalmology and Visual Science. 2015 ; Vol. 56, No. 12. pp. 7444-7450.
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Interactions of prosthetic and natural vision in animals with local retinal degeneration. / Lorach, Henri; Lei, Xin; Galambos, Ludwig; Kamins, Theodore; Mathieson, Keith; Dalal, Roopa; Huie, Philip; Harris, James; Palanker, Daniel.

In: Investigative Ophthalmology and Visual Science, Vol. 56, No. 12, 01.11.2015, p. 7444-7450.

Research output: Contribution to journalArticle

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