Interaction between charged lipid vesicles and point- or rod-like trivalent ions

Alberto Martin-Molina, Leo Lue, Manuel Quesada-Perez, Klemen Bohinc

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Abstract

This work examines the influence of the charge distribution of trivalent cations on their interaction with soft anionic particles, using a combination of experimental measurements and theoretical modelling. In particular, we perform electrophoresis measurements to determine the zeta-potential of anionic liposomes in the presence of spermidine and lanthanum cations. We work in a range of electrolyte concentration where a reversal in the electrophoretic mobility of the liposomes is expected; however, unlike the case of lanthanum cations, spermidine does not induce mobility reversal of liposomes. As a result, the charge distribution within the counterion appears to be a key factor. This conclusion is supported by a theory that accounts for intra-ionic correlations, which has previously been successfully used to describe the colloidal electric double layer. It allows us to model spermidine as rod-like ions and lanthanum cations as point-like ions in order to test the importance of the ionic geometry in the interactions with soft particles such as lipid vesicles.
Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume178
Early online date20 Feb 2019
DOIs
Publication statusPublished - 1 Jun 2019

Keywords

  • rod-like ions
  • trivalent ions
  • lipid vesicles

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