Abstract
Ultrafiltration of a ternary system lysozyme/sodium chloride/water is modelled through the integration of the surface force-pore flow (SFPF) model with the feed flow transport equations and recurring to computational fluid dynamics (CFD). Permeation experiments are performed using an ultrafiltration laboratory cell with a slit feed channel (h = 1.2 mm ≪ l = 200 mm, w = 30 mm) and a laboratory-made cellulose acetate membrane characterized by an hydraulic permeability of 5.9 × 10-11 m s-1 Pa-1 and a molecular weight cut-off of 60 kDa. The operating pressures ranged from 2 to 8 bar and the salt concentrations from 6 × 10-4 to 0.1 M. The ultrafiltration performance is simulated at different operating pressures and salt concentrations through multicomponent mass transfer modelling with incorporation of membrane/protein electrostatic interactions. The predictions of the lysozyme apparent rejection coefficients and permeation fluxes are in very good agreement with the experimental results.
| Language | English |
|---|---|
| Pages | 133-143 |
| Number of pages | 11 |
| Journal | Journal of Membrane Science |
| Volume | 286 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 15 Dec 2006 |
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Keywords
- CFD
- electrostatic interaction
- modelling
- multicomponent diffusion
- protein ultrafiltration
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Integrated modelling of lysozyme ultrafiltration. / Magueijo, Vítor; Semiao, Viriato; de Pinho, Maria Norberta.
In: Journal of Membrane Science, Vol. 286, No. 1-2, 15.12.2006, p. 133-143.Research output: Contribution to journal › Article
TY - JOUR
T1 - Integrated modelling of lysozyme ultrafiltration
AU - Magueijo, Vítor
AU - Semiao, Viriato
AU - de Pinho, Maria Norberta
PY - 2006/12/15
Y1 - 2006/12/15
N2 - Ultrafiltration of a ternary system lysozyme/sodium chloride/water is modelled through the integration of the surface force-pore flow (SFPF) model with the feed flow transport equations and recurring to computational fluid dynamics (CFD). Permeation experiments are performed using an ultrafiltration laboratory cell with a slit feed channel (h = 1.2 mm ≪ l = 200 mm, w = 30 mm) and a laboratory-made cellulose acetate membrane characterized by an hydraulic permeability of 5.9 × 10-11 m s-1 Pa-1 and a molecular weight cut-off of 60 kDa. The operating pressures ranged from 2 to 8 bar and the salt concentrations from 6 × 10-4 to 0.1 M. The ultrafiltration performance is simulated at different operating pressures and salt concentrations through multicomponent mass transfer modelling with incorporation of membrane/protein electrostatic interactions. The predictions of the lysozyme apparent rejection coefficients and permeation fluxes are in very good agreement with the experimental results.
AB - Ultrafiltration of a ternary system lysozyme/sodium chloride/water is modelled through the integration of the surface force-pore flow (SFPF) model with the feed flow transport equations and recurring to computational fluid dynamics (CFD). Permeation experiments are performed using an ultrafiltration laboratory cell with a slit feed channel (h = 1.2 mm ≪ l = 200 mm, w = 30 mm) and a laboratory-made cellulose acetate membrane characterized by an hydraulic permeability of 5.9 × 10-11 m s-1 Pa-1 and a molecular weight cut-off of 60 kDa. The operating pressures ranged from 2 to 8 bar and the salt concentrations from 6 × 10-4 to 0.1 M. The ultrafiltration performance is simulated at different operating pressures and salt concentrations through multicomponent mass transfer modelling with incorporation of membrane/protein electrostatic interactions. The predictions of the lysozyme apparent rejection coefficients and permeation fluxes are in very good agreement with the experimental results.
KW - CFD
KW - electrostatic interaction
KW - modelling
KW - multicomponent diffusion
KW - protein ultrafiltration
UR - http://www.scopus.com/inward/record.url?scp=33751187677&partnerID=8YFLogxK
U2 - 10.1016/j.memsci.2006.09.027
DO - 10.1016/j.memsci.2006.09.027
M3 - Article
VL - 286
SP - 133
EP - 143
JO - Journal of Membrane Science
T2 - Journal of Membrane Science
JF - Journal of Membrane Science
SN - 0376-7388
IS - 1-2
ER -