Abstract
Natural antioxidants are widely found in plants and exhibit biological effects with potential medicinal uses in conditions such as aging, cancer, inflammation, and cardiovascular diseases. Two types of assays are commonly employed to evaluate antioxidant activity. One measures the effect of plants and their constituents on lipid peroxidation, the other measures their electron or radical scavenging potential. None of these assays can identify potential individual antioxidant compounds within a complex mixture. This chapter describes the use of high-performance liquid chromatography linked to multivariate calibration techniques as a more advantageous method to generate an antioxidant profile and predict the identity of compounds associated with the antioxidant activity of herbal medicines. Data analysis applied to the integrated antioxidant activity fingerprints of the medicinal plant Pistacia atlantica is presented as a case example.
| Original language | English |
|---|---|
| Title of host publication | Herbal Formulations, Phytochemistry and Pharmacognosy |
| Subtitle of host publication | Natural Remedies and Drug Discovery |
| Editors | Mital Kaneria, Kalpna Rakholiya |
| Place of Publication | Amsterdam |
| Chapter | 16 |
| Pages | 219-240 |
| Number of pages | 22 |
| ISBN (Electronic) | 9780443153822 |
| DOIs | |
| Publication status | Published - 14 Jun 2024 |
Keywords
- Pistacia atlantica
- antioxidant activity
- chemometrics
- chromatographic fingerprints
- data analysis
- multivariate calibration