Integrated antioxidant activity fingerprints for herbal medicines: case study of Pistacia atlantica

Ziyad Ben Ahmed, Veronique Seidel, Mohamed Yousfi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Natural antioxidants are widely found in plants and exhibit biological effects with potential medicinal uses in conditions such as aging, cancer, inflammation, and cardiovascular diseases. Two types of assays are commonly employed to evaluate antioxidant activity. One measures the effect of plants and their constituents on lipid peroxidation, the other measures their electron or radical scavenging potential. None of these assays can identify potential individual antioxidant compounds within a complex mixture. This chapter describes the use of high-performance liquid chromatography linked to multivariate calibration techniques as a more advantageous method to generate an antioxidant profile and predict the identity of compounds associated with the antioxidant activity of herbal medicines. Data analysis applied to the integrated antioxidant activity fingerprints of the medicinal plant Pistacia atlantica is presented as a case example.
Original languageEnglish
Title of host publicationHerbal Formulations, Phytochemistry and Pharmacognosy
Subtitle of host publicationNatural Remedies and Drug Discovery
EditorsMital Kaneria, Kalpna Rakholiya
Place of PublicationAmsterdam
Chapter16
Pages219-240
Number of pages22
ISBN (Electronic)9780443153822
DOIs
Publication statusPublished - 14 Jun 2024

Keywords

  • Pistacia atlantica
  • antioxidant activity
  • chemometrics
  • chromatographic fingerprints
  • data analysis
  • multivariate calibration

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