Insulin-stimulated GLUT4 translocation – size is not everything!

Nia J. Bryant, Gwyn W. Gould

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Insulin-regulated trafficking of the facilitative glucose transporter GLUT4 has been studied in many cell types. The translocation of GLUT4 from intracellular membranes to the cell surface is often described as a highly specialised form of membrane traffic restricted to certain cell types such as fat and muscle, which are the major storage depots for insulin-stimulated glucose uptake. Here, we discuss evidence that favours the argument that rather than being restricted to specialised cell types, the machinery through which insulin regulates GLUT4 traffic is present in all cell types. This is an important point as it provides confidence in the use of experimentally tractable model systems to interrogate the trafficking itinerary of GLUT4.
Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume65
Early online date14 Mar 2020
DOIs
Publication statusPublished - 31 Aug 2020

Keywords

  • GLUT4
  • translocation
  • insulin

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