Inside cover: The synthesis of highly active iridium(I) complexes and their application in catalytic hydrogen isotope exchange (Adv. Synth. Catal. 17/2014)

Jack A. Brown, Alison Ruth Cochrane, Stephanie Irvine, William J. Kerr, Bhaskar Mondal, John A. Parkinson, Laura C. Paterson, Marc Reid, Tell Tuttle, Shalini Andersson, Göran N. Nilsson

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Abstract

The inside cover picture, by Kerr and co-workers depicts a series of robust, yet highly active Ir(I) complexes bearing specifically encumbered N-heterocyclic carbene and phosphine ligands. These complexes are extremely effective in hydrogen isotope exchange processes (with D or T), with low catalyst loadings, good levels of selectivity, and broad directing group applicability. The labelling of several complex drug molecules further highlights the catalysts’ utility. Mechanistic insight into the operation of these catalysts has also been provided by a combination of NMR and theoretical DFT studies.
Original languageEnglish
Pages (from-to)3474
Number of pages1
JournalAdvanced Synthesis and Catalysis
Volume356
Issue number17
Early online date18 Nov 2014
DOIs
Publication statusPublished - 24 Nov 2014

Keywords

  • hydrogen isotope exchange
  • iridium
  • catalysis
  • deuterium
  • tritium

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