The inside cover picture, by Kerr and co-workers depicts a series of robust, yet highly active Ir(I) complexes bearing specifically encumbered N-heterocyclic carbene and phosphine ligands. These complexes are extremely effective in hydrogen isotope exchange processes (with D or T), with low catalyst loadings, good levels of selectivity, and broad directing group applicability. The labelling of several complex drug molecules further highlights the catalysts’ utility. Mechanistic insight into the operation of these catalysts has also been provided by a combination of NMR and theoretical DFT studies.
- hydrogen isotope exchange
Brown, J. A., Cochrane, A. R., Irvine, S., Kerr, W. J., Mondal, B., Parkinson, J. A., Paterson, L. C., Reid, M., Tuttle, T., Andersson, S., & Nilsson, G. N. (2014). Inside cover: The synthesis of highly active iridium(I) complexes and their application in catalytic hydrogen isotope exchange (Adv. Synth. Catal. 17/2014). Advanced Synthesis and Catalysis, 356(17), 3474. https://doi.org/10.1002/adsc.201401054