Insecticidal rocaglamide derivatives from Aglaia duppereana

B. W. Nugroho; R. A. Edrada; B. Güssregen; V. Wray; L. Witte; P. Proksch

doi:10.1016/S0031-9422(96)00763-7

Insecticidal rocaglamide derivatives from Aglaia duppereana

B. W. Nugroho, R. A. Edrada, B. Güssregen, V. Wray, L. Witte, P. Proksch^*

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Twigs of Aglaia duppereana collected in Vietnam yielded the cyclopentatetrahydrobenzofuran, rocaglamide, and also six of its congeners. Whereas three of the isolated compounds were already known, four rocaglamide derivatives were new natural products. Elucidation of their structures and absolute configurations is described. All the rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into artificial diet. The LC ₅₀ for rocaglamide, which was one of the most active compounds encountered in this study, was 0.9 ppm, identical to that of azadirachtin used as a positive control in feeding experiments.

Original language	English
Pages (from-to)	1455-1461
Number of pages	7
Journal	Phytochemistry
Volume	44
Issue number	8
DOIs	https://doi.org/10.1016/S0031-9422(96)00763-7
Publication status	Published - 1 Apr 1997

Keywords

Aglaia duppereana
meliaceae
natural insecticides
rocaglamide derivatives
Spodoptera littoralis
structural elucidation
twigs

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10.1016/S0031-9422(96)00763-7

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title = "Insecticidal rocaglamide derivatives from Aglaia duppereana",

abstract = "Twigs of Aglaia duppereana collected in Vietnam yielded the cyclopentatetrahydrobenzofuran, rocaglamide, and also six of its congeners. Whereas three of the isolated compounds were already known, four rocaglamide derivatives were new natural products. Elucidation of their structures and absolute configurations is described. All the rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into artificial diet. The LC 50 for rocaglamide, which was one of the most active compounds encountered in this study, was 0.9 ppm, identical to that of azadirachtin used as a positive control in feeding experiments.",

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AU - Nugroho, B. W.

AU - Edrada, R. A.

AU - Güssregen, B.

AU - Wray, V.

AU - Witte, L.

AU - Proksch, P.

PY - 1997/4/1

Y1 - 1997/4/1

N2 - Twigs of Aglaia duppereana collected in Vietnam yielded the cyclopentatetrahydrobenzofuran, rocaglamide, and also six of its congeners. Whereas three of the isolated compounds were already known, four rocaglamide derivatives were new natural products. Elucidation of their structures and absolute configurations is described. All the rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into artificial diet. The LC 50 for rocaglamide, which was one of the most active compounds encountered in this study, was 0.9 ppm, identical to that of azadirachtin used as a positive control in feeding experiments.

AB - Twigs of Aglaia duppereana collected in Vietnam yielded the cyclopentatetrahydrobenzofuran, rocaglamide, and also six of its congeners. Whereas three of the isolated compounds were already known, four rocaglamide derivatives were new natural products. Elucidation of their structures and absolute configurations is described. All the rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into artificial diet. The LC 50 for rocaglamide, which was one of the most active compounds encountered in this study, was 0.9 ppm, identical to that of azadirachtin used as a positive control in feeding experiments.

KW - Aglaia duppereana

KW - meliaceae

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KW - rocaglamide derivatives

KW - Spodoptera littoralis

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KW - twigs

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Insecticidal rocaglamide derivatives from Aglaia duppereana

Abstract

Keywords

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