Inorganic nanoparticles in targeted drug delivery and imaging

Hélder A. Santos, Luis M. Bimbo, Leena Peltonen, Jouni Hirvonen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One of the major aims in modern nanomedicine is to develop delivery platforms for targeted delivery of therapeutics or imaging agents for improved therapeutic efficacy, reduced side effects, and increased diagnostic sensitivity. In this context, nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization, and biomedical applications. Currently, active and passive targeting and controlled drug release constitute some of the crucial functions identified to achieve a medical purpose. The limitation in targeting is currently associated, for example, with slow clearance, and systemic and local toxicity. Inorganic nanomaterials have been recognized for controllable properties on many levels for biomedical applications, such as mesoporous silica and silicon materials, gold, silver, quantum dots, and magnetic nanoparticles. These materials have great potential for cell labelling, biosensing, in vivo and magnetic imaging, targeting, and diagnostics. In this chapter, we start by introducing briefly some of the important aspects of inorganic nanoparticles in nanomedicine and describe their potential applications as nanocarriers or agents for biomedical applications, particularly for imaging/diagnostics and targeting. We then address some of the important aspects of the inorganic nanomaterials, including mesoporous silica and silicon materials, gold, silver, quantum dots, and magnetic nanoparticles in terms of their fabrication and synthesis, targeting, and imaging properties relevant for biomedical applications. Finally, we conclude the chapter with a brief overview of our visions of the future of the inorganic nanomaterials in drug delivery applications and their potentials for further translation into clinic.
Original languageEnglish
Title of host publicationTargeted Drug Delivery
Subtitle of host publicationConcepts and Design
EditorsPadma V. Devarajan, Jain Sanyog
Place of PublicationCham
PublisherSpringer International Publishing AG
Pages571-613
Number of pages43
ISBN (Print)9783319113548
DOIs
Publication statusPublished - 5 Nov 2014
Externally publishedYes

Publication series

NameAdvances in Delivery Science and Technology
PublisherSpringer International Publishing AG
ISSN (Print)2192-6204

Keywords

  • active and passing targeting
  • nanoparticles
  • mesoporous silica
  • mesoporous silicon
  • gold
  • silver
  • quantum dots
  • magnetic targeting
  • imaging
  • inorganic nanomaterials

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