Projects per year
Abstract
Oral drug delivery remains the preferred method of administration but BCS Class II drugs are not ideally suited to this due to their inherent poor solubility. Although a number of methods to increase solubility already exist, there is a need for manufacturing methods which are more flexible to the requirements of the individual patient. The current work aims to increase the solubility of poorly soluble drugs using the innovative manufacturing technique of inkjet printing with a view to creating formulations which are more easily tailored to the needs of the patient. Ultimately it has been established that printing the BCS Class II drug alone results in a crystalline product but on addition of a polymer this crystallinity is reduced and it is possible to print solid dispersions which are fully amorphous. Printing has also allowed greater control over drug distribution, which has allowed improved solubility overall. Additionally, the printer has proved itself capable of producing scalable products with a view to more patient centric dosage form manufacture.
Original language | English |
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Publication status | Published - 15 Nov 2017 |
Event | AAPS Annual Meeting and Exposition 2017 - San Diego Convention Center, San Diego, United States Duration: 12 Nov 2017 → 15 Nov 2017 |
Conference
Conference | AAPS Annual Meeting and Exposition 2017 |
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Abbreviated title | AAPS 2017 |
Country/Territory | United States |
City | San Diego |
Period | 12/11/17 → 15/11/17 |
Keywords
- drug delivery
- BCS Class II drugs
- solubility
Fingerprint
Dive into the research topics of 'Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs'. Together they form a unique fingerprint.Projects
- 1 Finished
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Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Turner, Alice
Halbert, G. (Principal Investigator), Florence, A. (Co-investigator) & Turner, A. (Research Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/14 → 10/05/19
Project: Research Studentship - Internally Allocated
Research output
- 1 Doctoral Thesis
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New Methods for the Production of Oral Dosage Forms
Turner, A. J., 10 May 2019, Glasgow: University of Strathclyde. 331 p.Research output: Thesis › Doctoral Thesis
Open AccessFile
Activities
- 1 Participation in conference
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The AAPS Annual Meeting and Exposition 2017
Turner, A. (Participant)
12 Nov 2017 → 15 Nov 2017Activity: Participating in or organising an event types › Participation in conference