Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs

Research output: Contribution to conferencePoster

Abstract

Oral drug delivery remains the preferred method of administration but BCS Class II drugs are not ideally suited to this due to their inherent poor solubility. Although a number of methods to increase solubility already exist, there is a need for manufacturing methods which are more flexible to the requirements of the individual patient. The current work aims to increase the solubility of poorly soluble drugs using the innovative manufacturing technique of inkjet printing with a view to creating formulations which are more easily tailored to the needs of the patient. Ultimately it has been established that printing the BCS Class II drug alone results in a crystalline product but on addition of a polymer this crystallinity is reduced and it is possible to print solid dispersions which are fully amorphous. Printing has also allowed greater control over drug distribution, which has allowed improved solubility overall. Additionally, the printer has proved itself capable of producing scalable products with a view to more patient centric dosage form manufacture.

Conference

ConferenceAAPS Annual Meeting and Exposition 2017
Abbreviated titleAAPS 2017
CountryUnited States
CitySan Diego
Period12/11/1715/11/17

Fingerprint

Printing
Dosage Forms
Solubility
Pharmaceutical Preparations
Drug and Narcotic Control
Polymers

Keywords

  • drug delivery
  • BCS Class II drugs
  • solubility

Cite this

Turner, A., Halbert, G., & Florence, A. (2017). Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs. Poster session presented at AAPS Annual Meeting and Exposition 2017, San Diego, United States.
Turner, A. ; Halbert, G. ; Florence, A. / Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs. Poster session presented at AAPS Annual Meeting and Exposition 2017, San Diego, United States.
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abstract = "Oral drug delivery remains the preferred method of administration but BCS Class II drugs are not ideally suited to this due to their inherent poor solubility. Although a number of methods to increase solubility already exist, there is a need for manufacturing methods which are more flexible to the requirements of the individual patient. The current work aims to increase the solubility of poorly soluble drugs using the innovative manufacturing technique of inkjet printing with a view to creating formulations which are more easily tailored to the needs of the patient. Ultimately it has been established that printing the BCS Class II drug alone results in a crystalline product but on addition of a polymer this crystallinity is reduced and it is possible to print solid dispersions which are fully amorphous. Printing has also allowed greater control over drug distribution, which has allowed improved solubility overall. Additionally, the printer has proved itself capable of producing scalable products with a view to more patient centric dosage form manufacture.",
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author = "A. Turner and G. Halbert and A. Florence",
year = "2017",
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day = "15",
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note = "AAPS Annual Meeting and Exposition 2017, AAPS 2017 ; Conference date: 12-11-2017 Through 15-11-2017",

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Turner, A, Halbert, G & Florence, A 2017, 'Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs' AAPS Annual Meeting and Exposition 2017, San Diego, United States, 12/11/17 - 15/11/17, .

Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs. / Turner, A.; Halbert, G.; Florence, A.

2017. Poster session presented at AAPS Annual Meeting and Exposition 2017, San Diego, United States.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs

AU - Turner, A.

AU - Halbert, G.

AU - Florence, A.

PY - 2017/11/15

Y1 - 2017/11/15

N2 - Oral drug delivery remains the preferred method of administration but BCS Class II drugs are not ideally suited to this due to their inherent poor solubility. Although a number of methods to increase solubility already exist, there is a need for manufacturing methods which are more flexible to the requirements of the individual patient. The current work aims to increase the solubility of poorly soluble drugs using the innovative manufacturing technique of inkjet printing with a view to creating formulations which are more easily tailored to the needs of the patient. Ultimately it has been established that printing the BCS Class II drug alone results in a crystalline product but on addition of a polymer this crystallinity is reduced and it is possible to print solid dispersions which are fully amorphous. Printing has also allowed greater control over drug distribution, which has allowed improved solubility overall. Additionally, the printer has proved itself capable of producing scalable products with a view to more patient centric dosage form manufacture.

AB - Oral drug delivery remains the preferred method of administration but BCS Class II drugs are not ideally suited to this due to their inherent poor solubility. Although a number of methods to increase solubility already exist, there is a need for manufacturing methods which are more flexible to the requirements of the individual patient. The current work aims to increase the solubility of poorly soluble drugs using the innovative manufacturing technique of inkjet printing with a view to creating formulations which are more easily tailored to the needs of the patient. Ultimately it has been established that printing the BCS Class II drug alone results in a crystalline product but on addition of a polymer this crystallinity is reduced and it is possible to print solid dispersions which are fully amorphous. Printing has also allowed greater control over drug distribution, which has allowed improved solubility overall. Additionally, the printer has proved itself capable of producing scalable products with a view to more patient centric dosage form manufacture.

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KW - BCS Class II drugs

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Turner A, Halbert G, Florence A. Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs. 2017. Poster session presented at AAPS Annual Meeting and Exposition 2017, San Diego, United States.