Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms

Sarahjane Wood; Gavin Halbert; Alastair Florence

Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms

Sarahjane Wood, Gavin Halbert, Alastair Florence

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster

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Abstract

The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.

Original language	English
Publication status	Published - 5 Sep 2016
Event	7th APS International PharmSci Conference - University of Strathclyde, Glasgow, United Kingdom Duration: 5 Sep 2016 → 7 Sep 2016 https://www.ukpharmsci.org/

Conference

Conference	7th APS International PharmSci Conference
Country	United Kingdom
City	Glasgow
Period	5/09/16 → 7/09/16
Internet address	https://www.ukpharmsci.org/

Keywords

injection moulding
dosage forms
oral drug delivery
hot metal extrusion
dissolution profile

Access to Document

Wood-etal-APS2016-Injection-mouldingAccepted author manuscript, 1.88 MB

https://www.ukpharmsci.org/default.asp

1 Finished

Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Mendez Torrecillas, Carlota
Halbert, G., Robertson, J. & Mendez Torrecillas, C.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/14 → 4/06/19
Project: Research Studentship - Internally Allocated

Cite this

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title = "Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms",

abstract = "The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.",

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T2 - 7th APS International PharmSci Conference

AU - Wood, Sarahjane

AU - Halbert, Gavin

AU - Florence, Alastair

PY - 2016/9/5

Y1 - 2016/9/5

N2 - The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.

AB - The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.

KW - injection moulding

KW - dosage forms

KW - oral drug delivery

KW - hot metal extrusion

KW - dissolution profile

UR - https://www.ukpharmsci.org/default.asp

M3 - Poster

Y2 - 5 September 2016 through 7 September 2016

ER -

Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms

Abstract

Conference

Keywords

Access to Document

Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Mendez Torrecillas, Carlota

Cite this