Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms

Sarahjane Wood, Gavin Halbert, Alastair Florence

Research output: Contribution to conference › Poster

Abstract

The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.
LanguageEnglish
Publication statusPublished - 5 Sep 2016
Event7th APS International PharmSci Conference - University of Strathclyde, Glasgow, United Kingdom
Duration: 5 Sep 2016 → 7 Sep 2016
https://www.ukpharmsci.org/

Conference

Conference7th APS International PharmSci Conference
CountryUnited Kingdom
CityGlasgow
Period5/09/16 → 7/09/16
Internet address

Fingerprint

Dosage Forms
Acetaminophen
Injections
Drug Interactions
Powders
Polymers
Research

Keywords

  • injection moulding
  • dosage forms
  • oral drug delivery
  • hot metal extrusion
  • dissolution profile

Cite this

Wood, S., Halbert, G., & Florence, A. (2016). Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.
Wood, Sarahjane ; Halbert, Gavin ; Florence, Alastair. / Injection moulding : a novel approach to the manufacture of homogenous immediate release solid oral dosage forms. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.
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Wood, S, Halbert, G & Florence, A 2016, 'Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms' 7th APS International PharmSci Conference, Glasgow, United Kingdom, 5/09/16 - 7/09/16, .

Injection moulding : a novel approach to the manufacture of homogenous immediate release solid oral dosage forms. / Wood, Sarahjane; Halbert, Gavin; Florence, Alastair.

2016. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.

Research output: Contribution to conference › Poster

TY - CONF

T1 - Injection moulding

T2 - a novel approach to the manufacture of homogenous immediate release solid oral dosage forms

AU - Wood, Sarahjane

AU - Halbert, Gavin

AU - Florence, Alastair

PY - 2016/9/5

Y1 - 2016/9/5

N2 - The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.

AB - The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.

KW - injection moulding

KW - dosage forms

KW - oral drug delivery

KW - hot metal extrusion

KW - dissolution profile

UR - https://www.ukpharmsci.org/default.asp

M3 - Poster

ER -

Wood S, Halbert G, Florence A. Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms. 2016. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.

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