Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion

HPMC-Affinisol paracetamol system

Research output: Contribution to conferenceAbstract

122 Downloads (Pure)

Abstract

The aim of this work is to: (1) Determine the viable processing window of HPMC-Affinisol polymer to use in hot melt extrusion. (2) Use this polymer for oral formulations with Paracetamol over a wide range of physical grades and determine the effect of API particle size on the nature of the resulting formulated mixtures.
(3) Assess if HME can be used to produce a consistent output with wide ranges in physical input API properties.
Original languageEnglish
Number of pages1
Publication statusAccepted/In press - 20 Jul 2016
Event2016 AAPS Annual meeting and exposition - Colorado Convention Center , Denver, United States
Duration: 13 Nov 201617 Nov 2016
http://www.aaps.org/annualmeeting/

Conference

Conference2016 AAPS Annual meeting and exposition
CountryUnited States
CityDenver
Period13/11/1617/11/16
Internet address

Fingerprint

Acetaminophen
Polymers
Particle Size

Keywords

  • hot melt extrusion
  • Affinisol
  • Plasdone
  • HPMC
  • copolymer
  • solid dispersion

Cite this

@conference{82d787b280774270b48afa9bb13a750b,
title = "Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion: HPMC-Affinisol paracetamol system",
abstract = "The aim of this work is to: (1) Determine the viable processing window of HPMC-Affinisol polymer to use in hot melt extrusion. (2) Use this polymer for oral formulations with Paracetamol over a wide range of physical grades and determine the effect of API particle size on the nature of the resulting formulated mixtures.(3) Assess if HME can be used to produce a consistent output with wide ranges in physical input API properties.",
keywords = "hot melt extrusion, Affinisol, Plasdone, HPMC, copolymer, solid dispersion",
author = "M.T. Islam and J. Robertson and A.J. Florence",
year = "2016",
month = "7",
day = "20",
language = "English",
note = "2016 AAPS Annual meeting and exposition ; Conference date: 13-11-2016 Through 17-11-2016",
url = "http://www.aaps.org/annualmeeting/",

}

Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion : HPMC-Affinisol paracetamol system. / Islam, M.T.; Robertson, J.; Florence, A.J.

2016. Abstract from 2016 AAPS Annual meeting and exposition, Denver, United States.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion

T2 - HPMC-Affinisol paracetamol system

AU - Islam, M.T.

AU - Robertson, J.

AU - Florence, A.J.

PY - 2016/7/20

Y1 - 2016/7/20

N2 - The aim of this work is to: (1) Determine the viable processing window of HPMC-Affinisol polymer to use in hot melt extrusion. (2) Use this polymer for oral formulations with Paracetamol over a wide range of physical grades and determine the effect of API particle size on the nature of the resulting formulated mixtures.(3) Assess if HME can be used to produce a consistent output with wide ranges in physical input API properties.

AB - The aim of this work is to: (1) Determine the viable processing window of HPMC-Affinisol polymer to use in hot melt extrusion. (2) Use this polymer for oral formulations with Paracetamol over a wide range of physical grades and determine the effect of API particle size on the nature of the resulting formulated mixtures.(3) Assess if HME can be used to produce a consistent output with wide ranges in physical input API properties.

KW - hot melt extrusion

KW - Affinisol

KW - Plasdone

KW - HPMC

KW - copolymer

KW - solid dispersion

UR - https://www.aaps.org

M3 - Abstract

ER -