Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion: HPMC-Affinisol paracetamol system

Research output: Contribution to conferenceAbstract

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Abstract

The aim of this work is to: (1) Determine the viable processing window of HPMC-Affinisol polymer to use in hot melt extrusion. (2) Use this polymer for oral formulations with Paracetamol over a wide range of physical grades and determine the effect of API particle size on the nature of the resulting formulated mixtures.
(3) Assess if HME can be used to produce a consistent output with wide ranges in physical input API properties.
Original languageEnglish
Number of pages1
Publication statusAccepted/In press - 20 Jul 2016
Event2016 AAPS Annual meeting and exposition - Colorado Convention Center , Denver, United States
Duration: 13 Nov 201617 Nov 2016
http://www.aaps.org/annualmeeting/

Conference

Conference2016 AAPS Annual meeting and exposition
CountryUnited States
CityDenver
Period13/11/1617/11/16
Internet address

Keywords

  • hot melt extrusion
  • Affinisol
  • Plasdone
  • HPMC
  • copolymer
  • solid dispersion
  • 2016 AAPS Annual meeting and exposition

    Tariq Islam (Participant)

    13 Nov 201617 Nov 2016

    Activity: Participating in or organising an event typesParticipation in conference

  • CMAC Internal Research Day

    Tariq Islam (Participant)

    10 Oct 201611 Oct 2016

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

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