Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2

Translated title of the contribution: Inhibitory effect of Persea americana Mill leaf aqueous extract and its fractions on PTP1B as therapeutic target for type 2 diabetes

Evangelina Marrero-Faz, Janet Sánchez-Calero, Louise Young, Alan Harvey

Research output: Contribution to journalArticle

7 Citations (Scopus)
258 Downloads (Pure)

Abstract

Persea Americana Mill (Lauraceae), is a popular plant in Cuba due to its nutritional and medicinal properties. The fruit of the plant is commonly known as avocado. The leaves of Persea americana Mill have been popularly used in the treatment of diabetes in countries in Latin America and Africa. The present study is aimed to explore one of the underlying mechanisms that mediate the antidiabetic efficacy of Persea americana Mill. The aqueous extract from the leaves of the plant and its fractions were evaluated on the inhibitory activity of the protein tyrosine phosphatase 1B (PTP1B) as target of type 2 diabetes. The results revealed that aqueous extract from P americana inhibited the enzymatic activity of PTP1B in an extract concentration dependent manner, resulting mainly active the most polar fraction. The present research demonstrated that aqueous extract from P americana and polar fraction (PaF10) have promissory antidiabetic properties mediated by PTP1B, which is a relevant mechanism involved on insulin resistance in type 2 diabetes.

Translated title of the contributionInhibitory effect of Persea americana Mill leaf aqueous extract and its fractions on PTP1B as therapeutic target for type 2 diabetes
Original languageUndefined/Unknown
Pages (from-to)144-151
Number of pages8
JournalBoletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas
Volume13
Issue number2
Publication statusPublished - 1 Jan 2014

Keywords

  • antidiabetic activity
  • persea americana Mill
  • PTP1B inhibitory activity
  • type 2 diabetes
  • inhibitory effect

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