Inhibitory effect of Persea americana Mill leaf aqueous extract and its fractions on PTP1B as therapeutic target for type 2 diabetes

Evangelina Marrero-Faz, Janet Sánchez-Calero, Louise Young, Alan Harvey

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Persea Americana Mill (Lauraceae), is a popular plant in Cuba due to its nutritional and medicinal properties. The fruit of the plant is commonly known as avocado. The leaves of Persea americana Mill have been popularly used in the treatment of diabetes in countries in Latin America and Africa. The present study is aimed to explore one of the underlying mechanisms that mediate the antidiabetic efficacy of Persea americana Mill. The aqueous extract from the leaves of the plant and its fractions were evaluated on the inhibitory activity of the protein tyrosine phosphatase 1B (PTP1B) as target of type 2 diabetes. The results revealed that aqueous extract from P americana inhibited the enzymatic activity of PTP1B in an extract concentration dependent manner, resulting mainly active the most polar fraction. The present research demonstrated that aqueous extract from P americana and polar fraction (PaF10) have promissory antidiabetic properties mediated by PTP1B, which is a relevant mechanism involved on insulin resistance in type 2 diabetes.

Translated title of the contributionInhibitory effect of Persea americana Mill leaf aqueous extract and its fractions on PTP1B as therapeutic target for type 2 diabetes
LanguageUndefined/Unknown
Pages144-151
Number of pages8
JournalBoletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas
Volume13
Issue number2
Publication statusPublished - 1 Jan 2014

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Non-Receptor Type 1 Protein Tyrosine Phosphatase
Persea
protein-tyrosine-phosphatase
Persea americana
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
hypoglycemic agents
therapeutics
extracts
Hypoglycemic Agents
leaves
Lauraceae
water
Cuba
Plant Leaves
medicinal properties
Latin America
avocados
Plant Extracts
Therapeutics

Keywords

  • antidiabetic activity
  • persea americana Mill
  • PTP1B inhibitory activity
  • type 2 diabetes
  • inhibitory effect

Cite this

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title = "Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terap{\'e}utica para la diabetes tipo 2",
abstract = "Persea Americana Mill (Lauraceae), is a popular plant in Cuba due to its nutritional and medicinal properties. The fruit of the plant is commonly known as avocado. The leaves of Persea americana Mill have been popularly used in the treatment of diabetes in countries in Latin America and Africa. The present study is aimed to explore one of the underlying mechanisms that mediate the antidiabetic efficacy of Persea americana Mill. The aqueous extract from the leaves of the plant and its fractions were evaluated on the inhibitory activity of the protein tyrosine phosphatase 1B (PTP1B) as target of type 2 diabetes. The results revealed that aqueous extract from P americana inhibited the enzymatic activity of PTP1B in an extract concentration dependent manner, resulting mainly active the most polar fraction. The present research demonstrated that aqueous extract from P americana and polar fraction (PaF10) have promissory antidiabetic properties mediated by PTP1B, which is a relevant mechanism involved on insulin resistance in type 2 diabetes.",
keywords = "antidiabetic activity, persea americana Mill, PTP1B inhibitory activity, type 2 diabetes, inhibitory effect",
author = "Evangelina Marrero-Faz and Janet S{\'a}nchez-Calero and Louise Young and Alan Harvey",
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journal = "Bolet{\'i}n Latinoamericano y del Caribe de Plantas Medicinales y Arom{\'a}ticas",
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T1 - Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2

AU - Marrero-Faz, Evangelina

AU - Sánchez-Calero, Janet

AU - Young, Louise

AU - Harvey, Alan

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Persea Americana Mill (Lauraceae), is a popular plant in Cuba due to its nutritional and medicinal properties. The fruit of the plant is commonly known as avocado. The leaves of Persea americana Mill have been popularly used in the treatment of diabetes in countries in Latin America and Africa. The present study is aimed to explore one of the underlying mechanisms that mediate the antidiabetic efficacy of Persea americana Mill. The aqueous extract from the leaves of the plant and its fractions were evaluated on the inhibitory activity of the protein tyrosine phosphatase 1B (PTP1B) as target of type 2 diabetes. The results revealed that aqueous extract from P americana inhibited the enzymatic activity of PTP1B in an extract concentration dependent manner, resulting mainly active the most polar fraction. The present research demonstrated that aqueous extract from P americana and polar fraction (PaF10) have promissory antidiabetic properties mediated by PTP1B, which is a relevant mechanism involved on insulin resistance in type 2 diabetes.

AB - Persea Americana Mill (Lauraceae), is a popular plant in Cuba due to its nutritional and medicinal properties. The fruit of the plant is commonly known as avocado. The leaves of Persea americana Mill have been popularly used in the treatment of diabetes in countries in Latin America and Africa. The present study is aimed to explore one of the underlying mechanisms that mediate the antidiabetic efficacy of Persea americana Mill. The aqueous extract from the leaves of the plant and its fractions were evaluated on the inhibitory activity of the protein tyrosine phosphatase 1B (PTP1B) as target of type 2 diabetes. The results revealed that aqueous extract from P americana inhibited the enzymatic activity of PTP1B in an extract concentration dependent manner, resulting mainly active the most polar fraction. The present research demonstrated that aqueous extract from P americana and polar fraction (PaF10) have promissory antidiabetic properties mediated by PTP1B, which is a relevant mechanism involved on insulin resistance in type 2 diabetes.

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KW - persea americana Mill

KW - PTP1B inhibitory activity

KW - type 2 diabetes

KW - inhibitory effect

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