Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells

D.B. Shennan, Jean Thomson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

It has been suggested that system L (LAT1/CD98hc) is up-regulated in cancer cells, including breast tumour cells, and is therefore a promising molecular target to inhibit or limit tumour cell growth. In view of this, we have examined the effect of BCH and other inhibitors of system L on the growth of MCF-7, ZR-75-1 and MDA-MB-231 cells. Treating cells with BCH markedly inhibited the metabolism of WST-1 in a dose-dependent fashion. Similarly, melphalan and D-leucine inhibited the growth of cultured breast cancer cells whereas MeAIB, an inhibitor of system A, was without effect. The effects of BCH and melphalan on cell growth were non-additive suggesting that both compounds were acting at a single locus. The results indicate that system L is required to maintain MCF-7, ZR-75-1 and MDA-MB-231 cell growth and support the notion that LAT1/CD98hc may be a suitable target to inhibit breast cancer progression.
LanguageEnglish
Pages885-889
Number of pages4
JournalOncology Reports
Volume20
Issue number4
DOIs
Publication statusPublished - Oct 2008

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Breast Neoplasms
Growth
Melphalan
Leucine
Neoplasms

Keywords

  • breast cancer
  • amino acid uptake
  • LAT1

Cite this

Shennan, D.B. ; Thomson, Jean. / Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. In: Oncology Reports. 2008 ; Vol. 20, No. 4. pp. 885-889.
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Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. / Shennan, D.B.; Thomson, Jean.

In: Oncology Reports, Vol. 20, No. 4, 10.2008, p. 885-889.

Research output: Contribution to journalArticle

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