Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.
- chronic arthritis
- monoclonal antibody
- protease activated receptor-2