Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

L. Dunning, J.C. Lockhart, W.R. Ferrell, R.J. Plevin, J.A. Gracie, I.B. McInnes, G.W. Boyd

Research output: Contribution to journalArticle

Abstract

Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.
Original languageEnglish
Pages (from-to)i38-i38
JournalRheumatology
Volume48
Issue numberSupplement 1
DOIs
Publication statusPublished - Apr 2009

Keywords

  • chronic arthritis
  • monoclonal antibody
  • protease activated receptor-2

Cite this