Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

L. Dunning, J.C. Lockhart, W.R. Ferrell, R.J. Plevin, J.A. Gracie, I.B. McInnes, G.W. Boyd

Research output: Contribution to journalArticle

Abstract

Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.
LanguageEnglish
Pagesi38-i38
JournalRheumatology
Volume48
Issue numberSupplement 1
DOIs
Publication statusPublished - Apr 2009

Fingerprint

PAR-2 Receptor
Arthritis
Monoclonal Antibodies
Experimental Arthritis
Joints
Ligands
Inflammation
Serine Proteases
G-Protein-Coupled Receptors
Inhibition (Psychology)

Keywords

  • chronic arthritis
  • monoclonal antibody
  • protease activated receptor-2

Cite this

Dunning, L., Lockhart, J. C., Ferrell, W. R., Plevin, R. J., Gracie, J. A., McInnes, I. B., & Boyd, G. W. (2009). Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2. Rheumatology, 48(Supplement 1), i38-i38. https://doi.org/10.1093/rheumatology/kep717
Dunning, L. ; Lockhart, J.C. ; Ferrell, W.R. ; Plevin, R.J. ; Gracie, J.A. ; McInnes, I.B. ; Boyd, G.W. / Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2. In: Rheumatology. 2009 ; Vol. 48, No. Supplement 1. pp. i38-i38.
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Dunning, L, Lockhart, JC, Ferrell, WR, Plevin, RJ, Gracie, JA, McInnes, IB & Boyd, GW 2009, 'Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2' Rheumatology, vol. 48, no. Supplement 1, pp. i38-i38. https://doi.org/10.1093/rheumatology/kep717

Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2. / Dunning, L.; Lockhart, J.C.; Ferrell, W.R.; Plevin, R.J.; Gracie, J.A.; McInnes, I.B.; Boyd, G.W.

In: Rheumatology, Vol. 48, No. Supplement 1, 04.2009, p. i38-i38.

Research output: Contribution to journalArticle

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AU - McInnes, I.B.

AU - Boyd, G.W.

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AB - Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.

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