Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

L. Dunning; J.C. Lockhart; W.R. Ferrell; R.J. Plevin; J.A. Gracie; I.B. McInnes; G.W. Boyd

doi:10.1093/rheumatology/kep717

Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

L. Dunning, J.C. Lockhart, W.R. Ferrell, R.J. Plevin, J.A. Gracie, I.B. McInnes, G.W. Boyd

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.

Original language	English
Pages (from-to)	i38-i38
Journal	Rheumatology
Volume	48
Issue number	Supplement 1
DOIs	https://doi.org/10.1093/rheumatology/kep717
Publication status	Published - Apr 2009

Keywords

chronic arthritis
monoclonal antibody
protease activated receptor-2

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10.1093/rheumatology/kep717

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abstract = "Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.",

keywords = "chronic arthritis, monoclonal antibody, protease activated receptor-2",

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T1 - Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

AU - Dunning, L.

AU - Lockhart, J.C.

AU - Ferrell, W.R.

AU - Plevin, R.J.

AU - Gracie, J.A.

AU - McInnes, I.B.

AU - Boyd, G.W.

PY - 2009/4

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N2 - Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.

AB - Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.

KW - chronic arthritis

KW - monoclonal antibody

KW - protease activated receptor-2

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DO - 10.1093/rheumatology/kep717

M3 - Article

SN - 1462-0324

VL - 48

SP - i38-i38

JO - Rheumatology

JF - Rheumatology

IS - Supplement 1

ER -

Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

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Keywords

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