Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease?

Research output: Contribution to conferencePoster

Abstract

Stents are small metal scaffold tubes, implanted into blocked coronary arteries in order to restore blood flow in patients with coronary heart disease. 1 The most advanced stents are drug-eluting stents (DES, which address the issue of vessel re-narrowing (restenosis) by inhibition of smooth muscle cell (SMC) proliferation. DES have limitations, most significantly occlusion of the vessel due to late stent thrombosis. 2 This partly arises due to inhibitory effects of the drugs on endothelial cells (EC), delaying recovery of the endothelium. 3 Recent research has identified Mdivi-1 (mitochondrial division inhibitor-1) as a potential drug candidate for preventing restenosis and other vascular diseases.4,5 This is due to Mdivi-1’s inhibitory effects on mitochondrial fission, preventing SMC proliferation. This study sought to characterise the effects of Mdivi-1 on EC function. Determinations of proliferation, migration and toxicity were carried out. Mitochondrial morphology assessment was undertaken using fluroesence microscopy. Results demonstrate a significant potential role for Mdivi-1 in the modulation of EC survival, proliferation and migration. This has important implications on Mdivi-1’s suitability as a substance within DES and as a treatment of vascular disease.

Conference

ConferenceTranslational Medicine CDT Conference
CountryUnited Kingdom
CityEdinburgh
Period31/05/161/06/16

Fingerprint

Mitochondrial Dynamics
Vascular Diseases
Stents
Endothelial Cells
Cell Proliferation
Smooth Muscle Myocytes
Drug-Eluting Stents
Pharmaceutical Preparations
Endothelium
Cell Movement
Coronary Disease
Blood Vessels
Microscopy
Cell Survival
Coronary Vessels
Thrombosis
Therapeutics
Metals
Research

Keywords

  • stents
  • heart disease

Cite this

Kaloya, S., McCarron, J., Chalmers, S., & McCormick, C. (2016). Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease?. Poster session presented at Translational Medicine CDT Conference, Edinburgh, United Kingdom.
@conference{96130f5c5ba543ae8eff80b7df876d3d,
title = "Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease?",
abstract = "Stents are small metal scaffold tubes, implanted into blocked coronary arteries in order to restore blood flow in patients with coronary heart disease. 1 The most advanced stents are drug-eluting stents (DES, which address the issue of vessel re-narrowing (restenosis) by inhibition of smooth muscle cell (SMC) proliferation. DES have limitations, most significantly occlusion of the vessel due to late stent thrombosis. 2 This partly arises due to inhibitory effects of the drugs on endothelial cells (EC), delaying recovery of the endothelium. 3 Recent research has identified Mdivi-1 (mitochondrial division inhibitor-1) as a potential drug candidate for preventing restenosis and other vascular diseases.4,5 This is due to Mdivi-1’s inhibitory effects on mitochondrial fission, preventing SMC proliferation. This study sought to characterise the effects of Mdivi-1 on EC function. Determinations of proliferation, migration and toxicity were carried out. Mitochondrial morphology assessment was undertaken using fluroesence microscopy. Results demonstrate a significant potential role for Mdivi-1 in the modulation of EC survival, proliferation and migration. This has important implications on Mdivi-1’s suitability as a substance within DES and as a treatment of vascular disease.",
keywords = "stents, heart disease",
author = "Sukhraj Kaloya and John McCarron and Susan Chalmers and Christopher McCormick",
year = "2016",
language = "English",
note = "Translational Medicine CDT Conference ; Conference date: 31-05-2016 Through 01-06-2016",

}

Kaloya, S, McCarron, J, Chalmers, S & McCormick, C 2016, 'Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease?' Translational Medicine CDT Conference, Edinburgh, United Kingdom, 31/05/16 - 1/06/16, .

Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease? / Kaloya, Sukhraj; McCarron, John; Chalmers, Susan; McCormick, Christopher.

2016. Poster session presented at Translational Medicine CDT Conference, Edinburgh, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease?

AU - Kaloya, Sukhraj

AU - McCarron, John

AU - Chalmers, Susan

AU - McCormick, Christopher

PY - 2016

Y1 - 2016

N2 - Stents are small metal scaffold tubes, implanted into blocked coronary arteries in order to restore blood flow in patients with coronary heart disease. 1 The most advanced stents are drug-eluting stents (DES, which address the issue of vessel re-narrowing (restenosis) by inhibition of smooth muscle cell (SMC) proliferation. DES have limitations, most significantly occlusion of the vessel due to late stent thrombosis. 2 This partly arises due to inhibitory effects of the drugs on endothelial cells (EC), delaying recovery of the endothelium. 3 Recent research has identified Mdivi-1 (mitochondrial division inhibitor-1) as a potential drug candidate for preventing restenosis and other vascular diseases.4,5 This is due to Mdivi-1’s inhibitory effects on mitochondrial fission, preventing SMC proliferation. This study sought to characterise the effects of Mdivi-1 on EC function. Determinations of proliferation, migration and toxicity were carried out. Mitochondrial morphology assessment was undertaken using fluroesence microscopy. Results demonstrate a significant potential role for Mdivi-1 in the modulation of EC survival, proliferation and migration. This has important implications on Mdivi-1’s suitability as a substance within DES and as a treatment of vascular disease.

AB - Stents are small metal scaffold tubes, implanted into blocked coronary arteries in order to restore blood flow in patients with coronary heart disease. 1 The most advanced stents are drug-eluting stents (DES, which address the issue of vessel re-narrowing (restenosis) by inhibition of smooth muscle cell (SMC) proliferation. DES have limitations, most significantly occlusion of the vessel due to late stent thrombosis. 2 This partly arises due to inhibitory effects of the drugs on endothelial cells (EC), delaying recovery of the endothelium. 3 Recent research has identified Mdivi-1 (mitochondrial division inhibitor-1) as a potential drug candidate for preventing restenosis and other vascular diseases.4,5 This is due to Mdivi-1’s inhibitory effects on mitochondrial fission, preventing SMC proliferation. This study sought to characterise the effects of Mdivi-1 on EC function. Determinations of proliferation, migration and toxicity were carried out. Mitochondrial morphology assessment was undertaken using fluroesence microscopy. Results demonstrate a significant potential role for Mdivi-1 in the modulation of EC survival, proliferation and migration. This has important implications on Mdivi-1’s suitability as a substance within DES and as a treatment of vascular disease.

KW - stents

KW - heart disease

M3 - Poster

ER -

Kaloya S, McCarron J, Chalmers S, McCormick C. Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease?. 2016. Poster session presented at Translational Medicine CDT Conference, Edinburgh, United Kingdom.