Inhibition of cell growth and glutathione depletion by calcium channel blockers

M. Akbar, C.J. Henderson, M. Helen Grant

    Research output: Contribution to journalArticle

    Abstract

    Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.
    LanguageEnglish
    Pages14-15
    Number of pages1
    JournalToxicology
    Volume253
    Issue number1-3
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Calcium Channel Blockers
    Cell growth
    Glutathione
    Stents
    Cell proliferation
    Growth
    Cell Proliferation
    Coatings
    Vascular Smooth Muscle
    Angioplasty
    Grafts
    Smooth Muscle Myocytes
    Muscle
    Transplants
    Equipment and Supplies

    Keywords

    • cell growth
    • glutathione
    • calcium channel blockers
    • bioengineering
    • toxicology

    Cite this

    Akbar, M. ; Henderson, C.J. ; Grant, M. Helen. / Inhibition of cell growth and glutathione depletion by calcium channel blockers. In: Toxicology. 2008 ; Vol. 253, No. 1-3. pp. 14-15.
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    Inhibition of cell growth and glutathione depletion by calcium channel blockers. / Akbar, M.; Henderson, C.J.; Grant, M. Helen.

    In: Toxicology, Vol. 253, No. 1-3, 2008, p. 14-15.

    Research output: Contribution to journalArticle

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    AB - Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.

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