Inhibition of cell growth and glutathione depletion by calcium channel blockers

M. Akbar; C.J. Henderson; M. Helen Grant

doi:10.1016/j.tox.2008.07.015

Inhibition of cell growth and glutathione depletion by calcium channel blockers

M. Akbar, C.J. Henderson, M. Helen Grant

Research output: Contribution to journal › Article › peer-review

Abstract

Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.

Original language	English
Pages (from-to)	14-15
Number of pages	1
Journal	Toxicology
Volume	253
Issue number	1-3
DOIs	https://doi.org/10.1016/j.tox.2008.07.015
Publication status	Published - 2008

Keywords

cell growth
glutathione
calcium channel blockers
bioengineering
toxicology

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10.1016/j.tox.2008.07.015

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title = "Inhibition of cell growth and glutathione depletion by calcium channel blockers",

abstract = "Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.",

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AB - Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.

KW - cell growth

KW - glutathione

KW - calcium channel blockers

KW - bioengineering

KW - toxicology

UR - http://dx.doi.org/10.1016/j.tox.2008.07.015

U2 - 10.1016/j.tox.2008.07.015

DO - 10.1016/j.tox.2008.07.015

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VL - 253

SP - 14

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JO - Toxicology

JF - Toxicology

IS - 1-3

ER -

Inhibition of cell growth and glutathione depletion by calcium channel blockers

Abstract

Keywords

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