Inhibition of cell growth and glutathione depletion by calcium channel blockers

    Research output: Contribution to journalArticle

    Abstract

    Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.
    Original languageEnglish
    Pages (from-to)14-15
    Number of pages1
    JournalToxicology
    Volume253
    Issue number1-3
    DOIs
    Publication statusPublished - 2008

    Keywords

    • cell growth
    • glutathione
    • calcium channel blockers
    • bioengineering
    • toxicology

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