Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs

R.H.C. Penny, H.J. Guise, T.P. Rolph, J.A. Tait, A.M. Johnston, S.A. Kempson, G. Gettinby

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of feeding the beta-adrenergic agonist salbutamol to pigs at levels between 0.5 and 5.0 mg/kg feed for different periods were studied in six experiments. The feet and ability to walk of pigs weighing 30 to 100 kg were examined at intervals. False sand-crack, white-line and heel erosion lesions were classified as mild or severe, and corns and wall haemorrhages were also recorded. At each examination the pig was given a grade for the overall severity of its foot lesions. Salbutamol fed at 1.0 to 5.0 mg/kg feed, for as little as 21 to 28 days, increased the frequency (P < 0.05 to 0.001) and often the severity (P < 0.05) of the foot lesions, the higher doses tending to produce more severe lesions, and the overall foot grades deteriorated (P < 0.001). The effects on both sexes were similar. No changes were observed when 0.5 mg/kg was fed for 56 days. Despite the severity of many of the foot lesions, the pigs became lame in only one experiment. Electron microscopy indicated that salbutamol was interfering with horn production, but light microscopy revealed no changes in skin sections. These findings suggested that salbutamol was not directly affecting the function of keratinocytes. Supplementing the diet of the pigs with biotin and methionine did not delay, or prevent, the effects of salbutamol.
LanguageEnglish
Pages374-381
Number of pages7
JournalVeterinary Record
Volume135
Issue number16
Publication statusPublished - 15 Oct 1994

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Hoof and Claw
beta-adrenergic agonists
Albuterol
claws
Horns
lesions (animal)
walking
Walking
Foot
finishing
Swine
swine
Callosities
Adrenergic beta-Agonists
Heel
keratinocytes
biotin
Biotin
Keratinocytes
skin (animal)

Keywords

  • repartitioning agent
  • meat quality
  • cimaterol
  • growth
  • swine

Cite this

Penny, R. H. C., Guise, H. J., Rolph, T. P., Tait, J. A., Johnston, A. M., Kempson, S. A., & Gettinby, G. (1994). Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs. Veterinary Record, 135(16), 374-381.
Penny, R.H.C. ; Guise, H.J. ; Rolph, T.P. ; Tait, J.A. ; Johnston, A.M. ; Kempson, S.A. ; Gettinby, G. / Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs. In: Veterinary Record. 1994 ; Vol. 135, No. 16. pp. 374-381.
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Penny, RHC, Guise, HJ, Rolph, TP, Tait, JA, Johnston, AM, Kempson, SA & Gettinby, G 1994, 'Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs' Veterinary Record, vol. 135, no. 16, pp. 374-381.

Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs. / Penny, R.H.C.; Guise, H.J.; Rolph, T.P.; Tait, J.A.; Johnston, A.M.; Kempson, S.A.; Gettinby, G.

In: Veterinary Record, Vol. 135, No. 16, 15.10.1994, p. 374-381.

Research output: Contribution to journalArticle

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T1 - Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs

AU - Penny, R.H.C.

AU - Guise, H.J.

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AU - Tait, J.A.

AU - Johnston, A.M.

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AB - The effects of feeding the beta-adrenergic agonist salbutamol to pigs at levels between 0.5 and 5.0 mg/kg feed for different periods were studied in six experiments. The feet and ability to walk of pigs weighing 30 to 100 kg were examined at intervals. False sand-crack, white-line and heel erosion lesions were classified as mild or severe, and corns and wall haemorrhages were also recorded. At each examination the pig was given a grade for the overall severity of its foot lesions. Salbutamol fed at 1.0 to 5.0 mg/kg feed, for as little as 21 to 28 days, increased the frequency (P < 0.05 to 0.001) and often the severity (P < 0.05) of the foot lesions, the higher doses tending to produce more severe lesions, and the overall foot grades deteriorated (P < 0.001). The effects on both sexes were similar. No changes were observed when 0.5 mg/kg was fed for 56 days. Despite the severity of many of the foot lesions, the pigs became lame in only one experiment. Electron microscopy indicated that salbutamol was interfering with horn production, but light microscopy revealed no changes in skin sections. These findings suggested that salbutamol was not directly affecting the function of keratinocytes. Supplementing the diet of the pigs with biotin and methionine did not delay, or prevent, the effects of salbutamol.

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KW - growth

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Penny RHC, Guise HJ, Rolph TP, Tait JA, Johnston AM, Kempson SA et al. Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs. Veterinary Record. 1994 Oct 15;135(16):374-381.