Influence of precursor solvent extraction on stable isotope signatures of methylamphetamine prepared from over-the-counter medicines using the Moscow and Hypophosphorous routes

Niamh Nic Daeid, Saravana Kumar Jayaram, W. J. Kerr, Wolfram Meier-Augenstein, Helen F. Kemp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A number of methods of clandestine manufacture of methylamphetamine involve the extraction and subsequent reaction of pseudoephedrine hydrochloride with other essential chemicals. The precursor can be easily extracted from over-the-counter medication widely available in the UK and elsewhere. Essential chemicals such as iodine and red phosphorous are also readily available and can be
extracted from iodine tinctures and matchboxes, respectively. This work reports the repetitive preparation of methylamphetamine using two popular routes (the Moscow and Hypophosphorous synthesis). The focus was on the extraction
solvent used for isolation of the precursor chemical and any consequential isotopic variation which may arise in the final product. Six batches of methylamphetamine were prepared under precisely controlled conditions for each synthetic route and for each of three different precursor extraction solvents. Synthesis of the final product from laboratory grade precursor using the synthetic methods described was used as a template for comparison. The resultant
IRMS data from all 48 prepared samples suggests some underlying trends in the identification of the synthetic route which may aid in the interpretation of IRMS data derived from clandestine samples.
Original languageEnglish
Pages (from-to)2931–2941
Number of pages11
JournalAnalytical and Bioanalytical Chemistry
Volume405
Issue number9
Early online date15 Dec 2012
DOIs
Publication statusPublished - Mar 2013

Keywords

  • precursor
  • solvent extraction
  • IRMS
  • methylamphetamine

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