Influence of cognitive abilities on prominence production in mild dysarthric patients with Parkinson’s disease

Tabea Thies, Doris Muecke, Anja Lowit, Julia Steffen, Elke Kalbe, Michael Barbe

Research output: Contribution to conferencePoster

Abstract

Objectives: This study investigates prominence marking (highlighting of prominent elements by adjusting speech parameters in the glottal, supraglottal and subglottal systems) and how this ability is correlated with motoric [1] and cognitive abilities [2] in patients with Parkinson’s disease (PwPD). Background: Dysarthric speech in PwPD affects different subsystems of speech involving phonation, articulation and respiration [3, 4]. It is unclear how much deterioration of these systems is tolerated until PwPD are no longer able to adjust speech parameters. Moreover, little is known about the relationship between cognitive functions and prosodic abilities. Methods: We collected production data from 38 native speakers of German: 19 PwPD (Med-On) with a mild to moderate motor impairment (UPDRS III, [5]) and 19 healthy age and gender matched controls. We recorded target words in two conditions (accented vs. unaccented) within mini-dialogues and analysed the acoustic speech parameters: intensity, pitch and vowel formants. Furthermore, we assessed cognitive functions in terms of executive functioning, attention control and working memory. Results: Comparisons between PwPD and controls revealed that the vowel space is smaller in PwPD right in the beginning of the developing dysarthria (p<.001). However, both groups were able to mark prominence by adjusting their vowel articulation and by increasing pitch and intensity. For the PwPD we found a relation between executive functions and the modulation of pitch and intensity (p<.01). The more severe the executive dysfunction the stronger intensity and pitch get modulated. Furthermore, the impairment of motor abilities within the PwPD group was accompanied by a decrease of the acoustic vowel space (p<.01). This results in an inefficient way of prominence marking and in a decrease in speech intelligibility and naturalness in an early stage of dysarthria. Conclusions: Our study shows a link between cognitive skills and speech production in natural sentence production, because PwPD with signs of mild dysarthria overused pitch and loudness in prominent positions, correlated with their level of executive functioning. Furthermore, lingual control decreases with an increase in motor impairment. Our results may be of clinical interest supporting the provision of therapeutic input at the early stages of the disease to preserve communication function. References [1] Hornykiewicz, O. 1998. Biochemical aspects of Parkinson's disease. Neurology, 51(2 Suppl 2), 2-9. [2] Kalbe, E., Rehberg, S. P., Heber, I., Kronenbuerger, M., Schulz, J. B., Storch, A., et al. (2016). Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatry, 87, 1099-1105. [3] Darley, F. L., Aronson, A. E., & Brown, J. R. 1969. Differential diagnostic patterns of dysarthria. Journal of Speech, Language, and Hearing Research, 12(2), 246-269. [4] Duffy, J. R. (2013). Motor Speech Disorders - Substrates, Differential Diagnosis, and Management. St. Louis, Elsevier, Mosby. [5] Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez‐Martin, P., ... & Dubois, B. 2008. Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results. Movement disorders, 23(15), 2129-2170.

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Aptitude
Parkinson Disease
Dysarthria
Cognition
Speech Acoustics
Speech Intelligibility
Speech Disorders
Phonation
Executive Function
Movement Disorders
Neurology
Short-Term Memory
Population Groups
Tongue
Acoustics
Hearing
Psychiatry
Respiration
Differential Diagnosis
Language

Keywords

  • cognitive abilities
  • Parkinson's disease
  • dysarthric patients

Cite this

Thies, T., Muecke, D., Lowit, A., Steffen, J., Kalbe, E., & Barbe, M. (2019). Influence of cognitive abilities on prominence production in mild dysarthric patients with Parkinson’s disease. Poster session presented at International Congress of Parkinson's Disease and Movement Disorders, Nice, France.
Thies, Tabea ; Muecke, Doris ; Lowit, Anja ; Steffen, Julia ; Kalbe, Elke ; Barbe, Michael. / Influence of cognitive abilities on prominence production in mild dysarthric patients with Parkinson’s disease. Poster session presented at International Congress of Parkinson's Disease and Movement Disorders, Nice, France.
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abstract = "Objectives: This study investigates prominence marking (highlighting of prominent elements by adjusting speech parameters in the glottal, supraglottal and subglottal systems) and how this ability is correlated with motoric [1] and cognitive abilities [2] in patients with Parkinson’s disease (PwPD). Background: Dysarthric speech in PwPD affects different subsystems of speech involving phonation, articulation and respiration [3, 4]. It is unclear how much deterioration of these systems is tolerated until PwPD are no longer able to adjust speech parameters. Moreover, little is known about the relationship between cognitive functions and prosodic abilities. Methods: We collected production data from 38 native speakers of German: 19 PwPD (Med-On) with a mild to moderate motor impairment (UPDRS III, [5]) and 19 healthy age and gender matched controls. We recorded target words in two conditions (accented vs. unaccented) within mini-dialogues and analysed the acoustic speech parameters: intensity, pitch and vowel formants. Furthermore, we assessed cognitive functions in terms of executive functioning, attention control and working memory. Results: Comparisons between PwPD and controls revealed that the vowel space is smaller in PwPD right in the beginning of the developing dysarthria (p<.001). However, both groups were able to mark prominence by adjusting their vowel articulation and by increasing pitch and intensity. For the PwPD we found a relation between executive functions and the modulation of pitch and intensity (p<.01). The more severe the executive dysfunction the stronger intensity and pitch get modulated. Furthermore, the impairment of motor abilities within the PwPD group was accompanied by a decrease of the acoustic vowel space (p<.01). This results in an inefficient way of prominence marking and in a decrease in speech intelligibility and naturalness in an early stage of dysarthria. Conclusions: Our study shows a link between cognitive skills and speech production in natural sentence production, because PwPD with signs of mild dysarthria overused pitch and loudness in prominent positions, correlated with their level of executive functioning. Furthermore, lingual control decreases with an increase in motor impairment. Our results may be of clinical interest supporting the provision of therapeutic input at the early stages of the disease to preserve communication function. References [1] Hornykiewicz, O. 1998. Biochemical aspects of Parkinson's disease. Neurology, 51(2 Suppl 2), 2-9. [2] Kalbe, E., Rehberg, S. P., Heber, I., Kronenbuerger, M., Schulz, J. B., Storch, A., et al. (2016). Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatry, 87, 1099-1105. [3] Darley, F. L., Aronson, A. E., & Brown, J. R. 1969. Differential diagnostic patterns of dysarthria. Journal of Speech, Language, and Hearing Research, 12(2), 246-269. [4] Duffy, J. R. (2013). Motor Speech Disorders - Substrates, Differential Diagnosis, and Management. St. Louis, Elsevier, Mosby. [5] Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez‐Martin, P., ... & Dubois, B. 2008. Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results. Movement disorders, 23(15), 2129-2170.",
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Thies, T, Muecke, D, Lowit, A, Steffen, J, Kalbe, E & Barbe, M 2019, 'Influence of cognitive abilities on prominence production in mild dysarthric patients with Parkinson’s disease' International Congress of Parkinson's Disease and Movement Disorders, Nice, France, 22/09/19 - 26/09/19, .

Influence of cognitive abilities on prominence production in mild dysarthric patients with Parkinson’s disease. / Thies, Tabea; Muecke, Doris; Lowit, Anja; Steffen, Julia ; Kalbe, Elke; Barbe, Michael.

2019. Poster session presented at International Congress of Parkinson's Disease and Movement Disorders, Nice, France.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Influence of cognitive abilities on prominence production in mild dysarthric patients with Parkinson’s disease

AU - Thies, Tabea

AU - Muecke, Doris

AU - Lowit, Anja

AU - Steffen, Julia

AU - Kalbe, Elke

AU - Barbe, Michael

PY - 2019/9/22

Y1 - 2019/9/22

N2 - Objectives: This study investigates prominence marking (highlighting of prominent elements by adjusting speech parameters in the glottal, supraglottal and subglottal systems) and how this ability is correlated with motoric [1] and cognitive abilities [2] in patients with Parkinson’s disease (PwPD). Background: Dysarthric speech in PwPD affects different subsystems of speech involving phonation, articulation and respiration [3, 4]. It is unclear how much deterioration of these systems is tolerated until PwPD are no longer able to adjust speech parameters. Moreover, little is known about the relationship between cognitive functions and prosodic abilities. Methods: We collected production data from 38 native speakers of German: 19 PwPD (Med-On) with a mild to moderate motor impairment (UPDRS III, [5]) and 19 healthy age and gender matched controls. We recorded target words in two conditions (accented vs. unaccented) within mini-dialogues and analysed the acoustic speech parameters: intensity, pitch and vowel formants. Furthermore, we assessed cognitive functions in terms of executive functioning, attention control and working memory. Results: Comparisons between PwPD and controls revealed that the vowel space is smaller in PwPD right in the beginning of the developing dysarthria (p<.001). However, both groups were able to mark prominence by adjusting their vowel articulation and by increasing pitch and intensity. For the PwPD we found a relation between executive functions and the modulation of pitch and intensity (p<.01). The more severe the executive dysfunction the stronger intensity and pitch get modulated. Furthermore, the impairment of motor abilities within the PwPD group was accompanied by a decrease of the acoustic vowel space (p<.01). This results in an inefficient way of prominence marking and in a decrease in speech intelligibility and naturalness in an early stage of dysarthria. Conclusions: Our study shows a link between cognitive skills and speech production in natural sentence production, because PwPD with signs of mild dysarthria overused pitch and loudness in prominent positions, correlated with their level of executive functioning. Furthermore, lingual control decreases with an increase in motor impairment. Our results may be of clinical interest supporting the provision of therapeutic input at the early stages of the disease to preserve communication function. References [1] Hornykiewicz, O. 1998. Biochemical aspects of Parkinson's disease. Neurology, 51(2 Suppl 2), 2-9. [2] Kalbe, E., Rehberg, S. P., Heber, I., Kronenbuerger, M., Schulz, J. B., Storch, A., et al. (2016). Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatry, 87, 1099-1105. [3] Darley, F. L., Aronson, A. E., & Brown, J. R. 1969. Differential diagnostic patterns of dysarthria. Journal of Speech, Language, and Hearing Research, 12(2), 246-269. [4] Duffy, J. R. (2013). Motor Speech Disorders - Substrates, Differential Diagnosis, and Management. St. Louis, Elsevier, Mosby. [5] Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez‐Martin, P., ... & Dubois, B. 2008. Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results. Movement disorders, 23(15), 2129-2170.

AB - Objectives: This study investigates prominence marking (highlighting of prominent elements by adjusting speech parameters in the glottal, supraglottal and subglottal systems) and how this ability is correlated with motoric [1] and cognitive abilities [2] in patients with Parkinson’s disease (PwPD). Background: Dysarthric speech in PwPD affects different subsystems of speech involving phonation, articulation and respiration [3, 4]. It is unclear how much deterioration of these systems is tolerated until PwPD are no longer able to adjust speech parameters. Moreover, little is known about the relationship between cognitive functions and prosodic abilities. Methods: We collected production data from 38 native speakers of German: 19 PwPD (Med-On) with a mild to moderate motor impairment (UPDRS III, [5]) and 19 healthy age and gender matched controls. We recorded target words in two conditions (accented vs. unaccented) within mini-dialogues and analysed the acoustic speech parameters: intensity, pitch and vowel formants. Furthermore, we assessed cognitive functions in terms of executive functioning, attention control and working memory. Results: Comparisons between PwPD and controls revealed that the vowel space is smaller in PwPD right in the beginning of the developing dysarthria (p<.001). However, both groups were able to mark prominence by adjusting their vowel articulation and by increasing pitch and intensity. For the PwPD we found a relation between executive functions and the modulation of pitch and intensity (p<.01). The more severe the executive dysfunction the stronger intensity and pitch get modulated. Furthermore, the impairment of motor abilities within the PwPD group was accompanied by a decrease of the acoustic vowel space (p<.01). This results in an inefficient way of prominence marking and in a decrease in speech intelligibility and naturalness in an early stage of dysarthria. Conclusions: Our study shows a link between cognitive skills and speech production in natural sentence production, because PwPD with signs of mild dysarthria overused pitch and loudness in prominent positions, correlated with their level of executive functioning. Furthermore, lingual control decreases with an increase in motor impairment. Our results may be of clinical interest supporting the provision of therapeutic input at the early stages of the disease to preserve communication function. References [1] Hornykiewicz, O. 1998. Biochemical aspects of Parkinson's disease. Neurology, 51(2 Suppl 2), 2-9. [2] Kalbe, E., Rehberg, S. P., Heber, I., Kronenbuerger, M., Schulz, J. B., Storch, A., et al. (2016). Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatry, 87, 1099-1105. [3] Darley, F. L., Aronson, A. E., & Brown, J. R. 1969. Differential diagnostic patterns of dysarthria. Journal of Speech, Language, and Hearing Research, 12(2), 246-269. [4] Duffy, J. R. (2013). Motor Speech Disorders - Substrates, Differential Diagnosis, and Management. St. Louis, Elsevier, Mosby. [5] Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez‐Martin, P., ... & Dubois, B. 2008. Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results. Movement disorders, 23(15), 2129-2170.

KW - cognitive abilities

KW - Parkinson's disease

KW - dysarthric patients

M3 - Poster

ER -

Thies T, Muecke D, Lowit A, Steffen J, Kalbe E, Barbe M. Influence of cognitive abilities on prominence production in mild dysarthric patients with Parkinson’s disease. 2019. Poster session presented at International Congress of Parkinson's Disease and Movement Disorders, Nice, France.