Inflammatory response to orthopaedic cobalt chromium alloy wear debris in a rodent air pouch model

M. Akbar, J.M. Brewer, M.H. Grant

Research output: Contribution to journalConference Contribution

28 Citations (Scopus)

Abstract

Cobalt chromium (Co-Cr) alloy metal-on-metal (MOM) hip resurfacing has become increasingly common in younger, more active patients. However, there is growing concern regarding levels of Co-Cr wear debris and ions released. Using the rodent air pouch model, described as a facsimile synovium, we assessed the inflammatory response to artificially generated Co-Cr wear debris.
Original languageEnglish
Pages (from-to)S199
JournalToxicology Letters
Volume196S
DOIs
Publication statusPublished - 17 Jul 2010

Keywords

  • hip resurfacing
  • cobalt chromium
  • rodent air pouch

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