Inflammatory response to orthopaedic cobalt chromium alloy wear debris in a rodent air pouch model

M. Akbar; J.M. Brewer; M.H. Grant

doi:10.1016/j.toxlet.2010.03.675

Inflammatory response to orthopaedic cobalt chromium alloy wear debris in a rodent air pouch model

M. Akbar, J.M. Brewer, M.H. Grant

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference Contribution › peer-review

28 Citations (Scopus)

Abstract

Cobalt chromium (Co-Cr) alloy metal-on-metal (MOM) hip resurfacing has become increasingly common in younger, more active patients. However, there is growing concern regarding levels of Co-Cr wear debris and ions released. Using the rodent air pouch model, described as a facsimile synovium, we assessed the inflammatory response to artificially generated Co-Cr wear debris.

Original language	English
Pages (from-to)	S199
Journal	Toxicology Letters
Volume	196S
DOIs	https://doi.org/10.1016/j.toxlet.2010.03.675
Publication status	Published - 17 Jul 2010

Keywords

hip resurfacing
cobalt chromium
rodent air pouch

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title = "Inflammatory response to orthopaedic cobalt chromium alloy wear debris in a rodent air pouch model",

abstract = "Cobalt chromium (Co-Cr) alloy metal-on-metal (MOM) hip resurfacing has become increasingly common in younger, more active patients. However, there is growing concern regarding levels of Co-Cr wear debris and ions released. Using the rodent air pouch model, described as a facsimile synovium, we assessed the inflammatory response to artificially generated Co-Cr wear debris.",

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AU - Akbar, M.

AU - Brewer, J.M.

AU - Grant, M.H.

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Y1 - 2010/7/17

N2 - Cobalt chromium (Co-Cr) alloy metal-on-metal (MOM) hip resurfacing has become increasingly common in younger, more active patients. However, there is growing concern regarding levels of Co-Cr wear debris and ions released. Using the rodent air pouch model, described as a facsimile synovium, we assessed the inflammatory response to artificially generated Co-Cr wear debris.

AB - Cobalt chromium (Co-Cr) alloy metal-on-metal (MOM) hip resurfacing has become increasingly common in younger, more active patients. However, there is growing concern regarding levels of Co-Cr wear debris and ions released. Using the rodent air pouch model, described as a facsimile synovium, we assessed the inflammatory response to artificially generated Co-Cr wear debris.

KW - hip resurfacing

KW - cobalt chromium

KW - rodent air pouch

U2 - 10.1016/j.toxlet.2010.03.675

DO - 10.1016/j.toxlet.2010.03.675

M3 - Conference Contribution

VL - 196S

SP - S199

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

ER -