Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline

B.J. Sahakian; P. Trayhurn; M. Wallace; R. Deeley; P. Winn; T.W. Robbins; B.J. Everitt

doi:10.1016/0304-3940(83)90320-8

Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline

B.J. Sahakian, P. Trayhurn, M. Wallace, R. Deeley, P. Winn, T.W. Robbins, B.J. Everitt

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Abstract

The effects of hypothalamic noradrenaline depletion produced by injection of 6-hydroxydopamine (6-OHDA) into the vicinity of cell bodies of the ventral noradrenergic bundle (VNAB) on weight gain, food intake and brown adipose tissue (BAT) activity (as measured by GDP binding in BAT mitochondria), were examined in rats at two different ages and under two different dietary conditions (chow and chow plus palatable cheese). VNAB lesions enhanced weight gain in the chow plus cheese diet conditions and produced small increases in feeding. These effects were parallelled by reductions in BAT activity in the VNAB group, suggesting a reduced capacity for dietary thermogenesis which may contribute to the significant overweight.

Original language	English
Pages (from-to)	321-326
Number of pages	6
Journal	Neuroscience Letters
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(83)90320-8
Publication status	Published - 9 Sept 1983

Keywords

brown adipose tissue
cafeteria diet
food intake
hypothalamus
noradrenaline
obesity
rat
thermogenesis
ventral noradrenergic bundle

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10.1016/0304-3940(83)90320-8

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abstract = "The effects of hypothalamic noradrenaline depletion produced by injection of 6-hydroxydopamine (6-OHDA) into the vicinity of cell bodies of the ventral noradrenergic bundle (VNAB) on weight gain, food intake and brown adipose tissue (BAT) activity (as measured by GDP binding in BAT mitochondria), were examined in rats at two different ages and under two different dietary conditions (chow and chow plus palatable cheese). VNAB lesions enhanced weight gain in the chow plus cheese diet conditions and produced small increases in feeding. These effects were parallelled by reductions in BAT activity in the VNAB group, suggesting a reduced capacity for dietary thermogenesis which may contribute to the significant overweight.",

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T1 - Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline

AU - Sahakian, B.J.

AU - Trayhurn, P.

AU - Wallace, M.

AU - Deeley, R.

AU - Winn, P.

AU - Robbins, T.W.

AU - Everitt, B.J.

PY - 1983/9/9

Y1 - 1983/9/9

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AB - The effects of hypothalamic noradrenaline depletion produced by injection of 6-hydroxydopamine (6-OHDA) into the vicinity of cell bodies of the ventral noradrenergic bundle (VNAB) on weight gain, food intake and brown adipose tissue (BAT) activity (as measured by GDP binding in BAT mitochondria), were examined in rats at two different ages and under two different dietary conditions (chow and chow plus palatable cheese). VNAB lesions enhanced weight gain in the chow plus cheese diet conditions and produced small increases in feeding. These effects were parallelled by reductions in BAT activity in the VNAB group, suggesting a reduced capacity for dietary thermogenesis which may contribute to the significant overweight.

KW - brown adipose tissue

KW - cafeteria diet

KW - food intake

KW - hypothalamus

KW - noradrenaline

KW - obesity

KW - rat

KW - thermogenesis

KW - ventral noradrenergic bundle

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline

Abstract

Keywords

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