Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients

M. Maniruzzaman, S. A. Ross, M. T. Islam, N. Scoutaris, A. Nair, D. Douroumis

Research output: Contribution to journalArticle

2 Citations (Scopus)
27 Downloads (Pure)

Abstract

The purpose of this study was to evaluate the performance of Neusilin® (NEU) a synthetic magnesium aluminometasilicate as inorganic drug carrier co-processed with the hydrophilic surfactants Labrasol and Labrafil to develop Tranilast (TLT) based solid dispersions using continuous melt extrusion (HME) processing. Twin – screw extrusion was optimized to develop various TLT/excipient/surfactant formulations followed by continuous capsule filling
in the absence of any downstream equipment. Physicochemical characterisation showed the existence of TLT in partially crystalline state in the porous network of inorganic NEU for all extruded formulations. Furthermore, in-line NIR studies revealed a possible intermolecular H–bonding formation between the drug and the carrier resulting in the increase of TLT dissolution rates. The capsules containing TLT extruded solid dispersions showed enhanced dissolution rates and compared with the marketed Rizaben® product.
Original languageEnglish
JournalDrug Development and Industrial Pharmacy
Early online date26 Jan 2017
Publication statusE-pub ahead of print - 26 Jan 2017

Keywords

  • extrusion
  • solid dispersions
  • inorganic excipients
  • drug-excipient interactions
  • dissolution
  • magnesium aluminometasilicate
  • inorganic drug carrier

Fingerprint Dive into the research topics of 'Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients'. Together they form a unique fingerprint.

  • Cite this

    Maniruzzaman, M., Ross, S. A., Islam, M. T., Scoutaris, N., Nair, A., & Douroumis, D. (2017). Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Drug Development and Industrial Pharmacy .