Inclusion of water insoluble drugs in amorphous silica nanoparticles

A Patil, A.A. Lafarga, M Chebrot, Dimitrios Lamprou, Andrew Urquhart, D. Douroumis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Amorphous silica nanoparticles (a-SiNPs) with high surface area and small pore size have been synthesized using a zwitterionic surfactant in acid media. The produced nanoparticles displayed large specific surface area (∼850 m2/g) with an average particles size of 45 nm. The loading efficiency was assessed by incorporating three model water insoluble active substances Carbamazepine (CBZ), Ibuprofen (IBU) and Cyclosporin (CyA) via passive loading and it was found to varying from 15-40%. The loaded silica nanoparticles were analyzed using X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) to investigate the state of the adsorbed active agents. CyA was found to be in amorphous state, IBU was partially crystalline while CBZ was transformed into form I. The dissolution profiles showed rapid release for CBZ while IBU and CyA demonstrated prolonged release for 24 hr. The viability of Caco-2 cells was not affected in the presence of a-SiNPs showing negligible cytotoxicity (85%) at high concentrations up to 15 mg/ml.
LanguageEnglish
Pages550-557
Number of pages8
JournalJournal of Biomedical Nanotechnology
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Silicon Dioxide
Nanoparticles
Ibuprofen
Carbamazepine
Silica
Water
Pharmaceutical Preparations
Powder Diffraction
Caco-2 Cells
Differential Scanning Calorimetry
Cytotoxicity
Particle Size
Surface-Active Agents
X-Ray Diffraction
Specific surface area
X ray powder diffraction
Cyclosporine
Pore size
Differential scanning calorimetry
Dissolution

Keywords

  • nanoparticles
  • mesoporous silica
  • drug dissolution rates
  • cytotoxicity

Cite this

Patil, A., Lafarga, A. A., Chebrot, M., Lamprou, D., Urquhart, A., & Douroumis, D. (2012). Inclusion of water insoluble drugs in amorphous silica nanoparticles. Journal of Biomedical Nanotechnology, 8(4), 550-557. https://doi.org/10.1166/jbn.2012.1409
Patil, A ; Lafarga, A.A. ; Chebrot, M ; Lamprou, Dimitrios ; Urquhart, Andrew ; Douroumis, D. / Inclusion of water insoluble drugs in amorphous silica nanoparticles. In: Journal of Biomedical Nanotechnology. 2012 ; Vol. 8, No. 4. pp. 550-557.
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Patil, A, Lafarga, AA, Chebrot, M, Lamprou, D, Urquhart, A & Douroumis, D 2012, 'Inclusion of water insoluble drugs in amorphous silica nanoparticles' Journal of Biomedical Nanotechnology, vol. 8, no. 4, pp. 550-557. https://doi.org/10.1166/jbn.2012.1409

Inclusion of water insoluble drugs in amorphous silica nanoparticles. / Patil, A; Lafarga, A.A.; Chebrot, M; Lamprou, Dimitrios; Urquhart, Andrew; Douroumis, D.

In: Journal of Biomedical Nanotechnology, Vol. 8, No. 4, 08.2012, p. 550-557.

Research output: Contribution to journalArticle

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Patil A, Lafarga AA, Chebrot M, Lamprou D, Urquhart A, Douroumis D. Inclusion of water insoluble drugs in amorphous silica nanoparticles. Journal of Biomedical Nanotechnology. 2012 Aug;8(4):550-557. https://doi.org/10.1166/jbn.2012.1409