In vivo imaging of drug delivery systems in the gastrointestinal tract

Werner Weitschies, Clive Wilson

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

An essential basis for the understanding of the complex interplay between oral drugdeliverysystems and gastrointestinal physiology is the ability to relate deposition of the dosage form to the plasma concentration time profile. The pharmaceutical scientist requires an array of methods that provide information on formulation disposition without influencing the physiological process, commonly termed “non-invasive” imaging modalities. In this paper, a short historical view on the suitability of different imaging modalities for the investigation of the fate of drugdeliverysystems in the GI tract is given. The focus of the review is the presentation of currently mostly used methodologies scintigraphy, magnetic tracking techniques like magnetic marker monitoring (MMM), magnetic moment imaging (MMI), AC biosusceptometry (ACB) and magnetic resonance imaging and the discussion of their strengths and weaknesses.
LanguageEnglish
Pages216-226
Number of pages11
JournalInternational Journal of Pharmaceutics
Volume417
Issue number1-2
DOIs
Publication statusPublished - 2011

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Physiological Phenomena
Dosage Forms
Drug Delivery Systems
Radionuclide Imaging
Gastrointestinal Tract
Magnetic Resonance Imaging
Pharmaceutical Preparations

Keywords

  • in vivoimaging
  • drug delivery systems
  • gamma scintigraphy
  • magnetic marker monitoring
  • magnetic moment imaging
  • magnetic resonance imaging
  • magnetic pill tracking
  • AC biosusceptometry

Cite this

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In vivo imaging of drug delivery systems in the gastrointestinal tract. / Weitschies, Werner; Wilson, Clive.

In: International Journal of Pharmaceutics, Vol. 417, No. 1-2, 2011, p. 216-226.

Research output: Contribution to journalArticle

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