In vitro variability in propofol absorption by different membrane oxygenators

S. Hickey, I. Quasim, J.D. Gaylor

    Research output: Contribution to conferenceOther

    Abstract

    Meeting abstract focusing on the sequestration of drugs, such as fentanyl [1,2], thiopental, nitroglycerine and propofol [3] in the extracorporeal circuit in vitro. This phenomenon can change the pharmacokinetic behaviour of drugs during cardiopulmonary bypass, thus potentially leading to problems in achieving adequate dosing regimens. The aim of this in vitro laboratory study was to compare the binding of propofol to different oxygenator membranes, and to examine the effects of the type of prime solution and temperature on the rate of binding. The SM-35 membrane bound significantly more propofol than the membranes from the CML and the SAFE II. Binding of propofol in diluted blood was significantly less than in crystalloid solution. Temperature had little effect on propofol binding in either prime solution type.
    Original languageEnglish
    Number of pages1
    DOIs
    Publication statusPublished - 2001
    Event18th Spring Meeting of the Association of Cardiothoracic Anaesthetists - Cambridge, United Kingdom
    Duration: 22 Jun 2001 → …

    Conference

    Conference18th Spring Meeting of the Association of Cardiothoracic Anaesthetists
    CountryUnited Kingdom
    CityCambridge
    Period22/06/01 → …

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    Keywords

    • in vitro variability
    • drugs
    • bioscience
    • physiology
    • bioengineering

    Cite this

    Hickey, S., Quasim, I., & Gaylor, J. D. (2001). In vitro variability in propofol absorption by different membrane oxygenators. 18th Spring Meeting of the Association of Cardiothoracic Anaesthetists, Cambridge, United Kingdom. https://doi.org/10.1186/cc1037