Meeting abstract focusing on the sequestration of drugs, such as fentanyl [1,2], thiopental, nitroglycerine and propofol  in the extracorporeal circuit in vitro. This phenomenon can change the pharmacokinetic behaviour of drugs during cardiopulmonary bypass, thus potentially leading to problems in achieving adequate dosing regimens. The aim of this in vitro laboratory study was to compare the binding of propofol to different oxygenator membranes, and to examine the effects of the type of prime solution and temperature on the rate of binding. The SM-35 membrane bound significantly more propofol than the membranes from the CML and the SAFE II. Binding of propofol in diluted blood was significantly less than in crystalloid solution. Temperature had little effect on propofol binding in either prime solution type.
|Number of pages||1|
|Publication status||Published - 2001|
|Event||18th Spring Meeting of the Association of Cardiothoracic Anaesthetists - Cambridge, United Kingdom|
Duration: 22 Jun 2001 → …
|Conference||18th Spring Meeting of the Association of Cardiothoracic Anaesthetists|
|Period||22/06/01 → …|
- in vitro variability