In-vitro permeation of drugs into porcine hair follicles: is it quantitatively equivalent to permeation into human hair follicles?

V.M. Meidan, Y. Frum, G.M. Eccleston

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

It is already well-established that the general permeability properties of porcine skin are close to those of human skin. However, very little is known with respect to drug absorption into hair follicles and the similarities if any between the two types of tissue. The aim of this study was to use the skin sandwich system to quantify follicular drug absorption into porcine hair follicles. To our knowledge, this is the first time that the skin sandwich has been extended to porcine tissue. For this purpose, seven different drugs - estradiol, corticosterone, hydrocortisone, aldosterone, cimetidine, deoxyadenosine and adenosine - exhibiting a wide range of log octanol-water partition coefficients (log Ko/w), but comparable molecular weights, were chosen as candidate solutes. The results showed a parabolic profile with maximal follicular contribution occurring at intermediate log Ko/w values. Linear regression analysis indicated that the follicular contributions in porcine skin correlated well with previously published follicular contributions in human skin (r2 = 0.87). The novelty of this research is that we show that porcine tissue is a good surrogate for modelling human skin permeability within the specific context of quantifying drug absorption into hair follicles.
Original languageEnglish
Pages (from-to)145-151
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume60
Issue number2
DOIs
Publication statusPublished - 2008

Keywords

  • in-vitro permeation
  • drugs
  • porcine hair
  • human hair follicles
  • pharmacological sciences
  • pharmacy
  • pharmacology

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