In vitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery

Dana Gourevich, Alexander Volovick, Osnat Dogadkin, Lijun Wang, Helen Elizabeth Mulvana, Yoav Medan, Andreas Melzer, Sandy Cochran

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ultrasound-mediated targeted drug delivery is a therapeutic modality under development with the potential to treat cancer. Its ability to produce local hyperthermia and cell poration through cavitation non-invasively makes it a candidate to trigger drug delivery. Hyperthermia offers greater potential for control, particularly with magnetic resonance imaging temperature measurement. However, cavitation may offer reduced treatment times, with real-time measurement of ultrasonic spectra indicating drug dose and treatment success. Here, a clinical magnetic resonance imaging-guided focused ultrasound surgery system was used to study ultrasound-mediated targeted drug delivery in vitro. Drug uptake into breast cancer cells in the vicinity of ultrasound contrast agent was correlated with occurrence and quantity of stable and inertial cavitation, classified according to subharmonic spectra. During stable cavitation, intracellular drug uptake increased by a factor up to 3.2 compared with the control. Reported here are the value of cavitation monitoring with a clinical system and its subsequent employment for dose optimization.
Original languageEnglish
Pages (from-to)1853-1864
Number of pages12
JournalUltrasound in Medicine and Biology
Volume41
Issue number7
DOIs
Publication statusPublished - 31 Jul 2015

Keywords

  • cancer cell
  • cavitation
  • focussed ultrasound
  • microbubbles
  • subharmonic
  • targeted drug delivery
  • ultrasound contrast agent

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