In-vitro / in-vivo correlation of pulsatile drug release from press coated tablet formulations: a pharmacoscintigraphic study in the beagle dog

M. Ghimire, F.J. McInnes, D.G. Watson, A. Mullen, H. Stevens

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34 Citations (Scopus)

Abstract

The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release, consisting of a rapidly disintegrating theophylline core tablet, press-coated with barrier granules containing glyceryl behenate (GB) and low-substituted hydroxypropylcellulose (L-HPC). The PCTs showed pulsatile release with a lag time dependent upon the GB and L-HPC composition of the barrier layer. In-vivo γ-scintigraphic studies were carried out for PCTs containing GB:L-HPC at 65:35 w/w and 75:25 w/w in the barrier layer in four beagle dogs, in either the fed or fasted state. The in-vivo lag time in both the fed and fasted states did not differ significantly (p > 0.05) from the in-vitro lag time. Additionally, no significant difference (p < 0.05) between in-vivo fed and fasted disintegration times was observed, demonstrating that in-vivo performance of the PCT was not influenced by the presence or absence of food in the gastrointestinal tract. A distinct lag time was obtained prior to the appearance of drug in plasma and correlated (R2 = 0.98) with disintegration time observed from scintigraphic images. However, following disintegration, no difference in pharmacokinetic parameters (AUC0–6 dis, Kel, Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery.
LanguageEnglish
Pages515-523
Number of pages9
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume67
Issue number2
DOIs
Publication statusPublished - 2007

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Tablets
Dogs
Drug Compounding
Theophylline
In Vitro Techniques
Drug Liberation
Gastrointestinal Tract
Pharmacokinetics
Food
Pharmaceutical Preparations
glyceryl behenate
hydroxypropylcellulose

Keywords

  • press-coated tablets
  • IVIVC
  • lag time
  • pharmacoscintigraphy
  • pulsatile release

Cite this

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title = "In-vitro / in-vivo correlation of pulsatile drug release from press coated tablet formulations: a pharmacoscintigraphic study in the beagle dog",
abstract = "The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release, consisting of a rapidly disintegrating theophylline core tablet, press-coated with barrier granules containing glyceryl behenate (GB) and low-substituted hydroxypropylcellulose (L-HPC). The PCTs showed pulsatile release with a lag time dependent upon the GB and L-HPC composition of the barrier layer. In-vivo γ-scintigraphic studies were carried out for PCTs containing GB:L-HPC at 65:35 w/w and 75:25 w/w in the barrier layer in four beagle dogs, in either the fed or fasted state. The in-vivo lag time in both the fed and fasted states did not differ significantly (p > 0.05) from the in-vitro lag time. Additionally, no significant difference (p < 0.05) between in-vivo fed and fasted disintegration times was observed, demonstrating that in-vivo performance of the PCT was not influenced by the presence or absence of food in the gastrointestinal tract. A distinct lag time was obtained prior to the appearance of drug in plasma and correlated (R2 = 0.98) with disintegration time observed from scintigraphic images. However, following disintegration, no difference in pharmacokinetic parameters (AUC0–6 dis, Kel, Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery.",
keywords = "press-coated tablets, IVIVC , lag time, pharmacoscintigraphy , pulsatile release",
author = "M. Ghimire and F.J. McInnes and D.G. Watson and A. Mullen and H. Stevens",
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T1 - In-vitro / in-vivo correlation of pulsatile drug release from press coated tablet formulations: a pharmacoscintigraphic study in the beagle dog

AU - Ghimire, M.

AU - McInnes, F.J.

AU - Watson, D.G.

AU - Mullen, A.

AU - Stevens, H.

PY - 2007

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N2 - The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release, consisting of a rapidly disintegrating theophylline core tablet, press-coated with barrier granules containing glyceryl behenate (GB) and low-substituted hydroxypropylcellulose (L-HPC). The PCTs showed pulsatile release with a lag time dependent upon the GB and L-HPC composition of the barrier layer. In-vivo γ-scintigraphic studies were carried out for PCTs containing GB:L-HPC at 65:35 w/w and 75:25 w/w in the barrier layer in four beagle dogs, in either the fed or fasted state. The in-vivo lag time in both the fed and fasted states did not differ significantly (p > 0.05) from the in-vitro lag time. Additionally, no significant difference (p < 0.05) between in-vivo fed and fasted disintegration times was observed, demonstrating that in-vivo performance of the PCT was not influenced by the presence or absence of food in the gastrointestinal tract. A distinct lag time was obtained prior to the appearance of drug in plasma and correlated (R2 = 0.98) with disintegration time observed from scintigraphic images. However, following disintegration, no difference in pharmacokinetic parameters (AUC0–6 dis, Kel, Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery.

AB - The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release, consisting of a rapidly disintegrating theophylline core tablet, press-coated with barrier granules containing glyceryl behenate (GB) and low-substituted hydroxypropylcellulose (L-HPC). The PCTs showed pulsatile release with a lag time dependent upon the GB and L-HPC composition of the barrier layer. In-vivo γ-scintigraphic studies were carried out for PCTs containing GB:L-HPC at 65:35 w/w and 75:25 w/w in the barrier layer in four beagle dogs, in either the fed or fasted state. The in-vivo lag time in both the fed and fasted states did not differ significantly (p > 0.05) from the in-vitro lag time. Additionally, no significant difference (p < 0.05) between in-vivo fed and fasted disintegration times was observed, demonstrating that in-vivo performance of the PCT was not influenced by the presence or absence of food in the gastrointestinal tract. A distinct lag time was obtained prior to the appearance of drug in plasma and correlated (R2 = 0.98) with disintegration time observed from scintigraphic images. However, following disintegration, no difference in pharmacokinetic parameters (AUC0–6 dis, Kel, Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery.

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KW - lag time

KW - pharmacoscintigraphy

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