Abstract
| Language | English |
|---|---|
| Pages | 515-523 |
| Number of pages | 9 |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 67 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2007 |
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Keywords
- press-coated tablets
- IVIVC
- lag time
- pharmacoscintigraphy
- pulsatile release
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In-vitro / in-vivo correlation of pulsatile drug release from press coated tablet formulations: a pharmacoscintigraphic study in the beagle dog. / Ghimire, M.; McInnes, F.J.; Watson, D.G.; Mullen, A.; Stevens, H.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 67, No. 2, 2007, p. 515-523.Research output: Contribution to journal › Article
TY - JOUR
T1 - In-vitro / in-vivo correlation of pulsatile drug release from press coated tablet formulations: a pharmacoscintigraphic study in the beagle dog
AU - Ghimire, M.
AU - McInnes, F.J.
AU - Watson, D.G.
AU - Mullen, A.
AU - Stevens, H.
PY - 2007
Y1 - 2007
N2 - The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release, consisting of a rapidly disintegrating theophylline core tablet, press-coated with barrier granules containing glyceryl behenate (GB) and low-substituted hydroxypropylcellulose (L-HPC). The PCTs showed pulsatile release with a lag time dependent upon the GB and L-HPC composition of the barrier layer. In-vivo γ-scintigraphic studies were carried out for PCTs containing GB:L-HPC at 65:35 w/w and 75:25 w/w in the barrier layer in four beagle dogs, in either the fed or fasted state. The in-vivo lag time in both the fed and fasted states did not differ significantly (p > 0.05) from the in-vitro lag time. Additionally, no significant difference (p < 0.05) between in-vivo fed and fasted disintegration times was observed, demonstrating that in-vivo performance of the PCT was not influenced by the presence or absence of food in the gastrointestinal tract. A distinct lag time was obtained prior to the appearance of drug in plasma and correlated (R2 = 0.98) with disintegration time observed from scintigraphic images. However, following disintegration, no difference in pharmacokinetic parameters (AUC0–6 dis, Kel, Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery.
AB - The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release, consisting of a rapidly disintegrating theophylline core tablet, press-coated with barrier granules containing glyceryl behenate (GB) and low-substituted hydroxypropylcellulose (L-HPC). The PCTs showed pulsatile release with a lag time dependent upon the GB and L-HPC composition of the barrier layer. In-vivo γ-scintigraphic studies were carried out for PCTs containing GB:L-HPC at 65:35 w/w and 75:25 w/w in the barrier layer in four beagle dogs, in either the fed or fasted state. The in-vivo lag time in both the fed and fasted states did not differ significantly (p > 0.05) from the in-vitro lag time. Additionally, no significant difference (p < 0.05) between in-vivo fed and fasted disintegration times was observed, demonstrating that in-vivo performance of the PCT was not influenced by the presence or absence of food in the gastrointestinal tract. A distinct lag time was obtained prior to the appearance of drug in plasma and correlated (R2 = 0.98) with disintegration time observed from scintigraphic images. However, following disintegration, no difference in pharmacokinetic parameters (AUC0–6 dis, Kel, Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery.
KW - press-coated tablets
KW - IVIVC
KW - lag time
KW - pharmacoscintigraphy
KW - pulsatile release
U2 - 10.1016/j.ejpb.2007.03.002
DO - 10.1016/j.ejpb.2007.03.002
M3 - Article
VL - 67
SP - 515
EP - 523
JO - European Journal of Pharmaceutics and Biopharmaceutics
T2 - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
SN - 0939-6411
IS - 2
ER -