In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug

J.S. Boateng, K.H. Matthews, A.D. Auffret, M.J. Humphrey, H.N.E. Stevens, G.M. Eccleston

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Drug dissolution and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of drug release from the two systems. The formulations were prepared by freeze-drying (wafers) or drying in air (films), the hydrated gel of the polymer containing paracetamol as a model soluble drug. Scanning electron microscopy (SEM) was used to examine differences between the physical structure of the wafers and films. Dissolution studies were performed using an exchange cell and drug release was measured by UV spectroscopy at 242 nm. The effects of drug loading, polymer content and amount of glycerol (films) on the release characteristics of paracetamol were investigated. The release profiles of paracetamol from the wafers and films were also compared. A digital camera was used to observe the times to complete hydration and dissolution of the wafers containing different amounts of CMC and how that impacts on drug release rates. Both formulations showed sustained type drug release that was modelled by the Korsmeyer-Peppas equation. Changes in the concentration of drug and glycerol (films) did not significantly alter the rate of drug release while increasing polymer content significantly decreased the rate of drug release from both formulations. The results show that the rate of paracetamol release was faster from the wafers than the corresponding films due to differences in their physical structures. The wafers which formed a porous network, hydrated faster than the more dense and continuous, (non-porous) sheet-like structure of the films.
LanguageEnglish
Pages66-72
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume378
Issue number1-2
DOIs
Publication statusPublished - 13 Aug 2009

Fingerprint

Acetaminophen
Pharmaceutical Preparations
Polymers
Carboxymethylcellulose Sodium
Glycerol
Freeze Drying
In Vitro Techniques
Drug Liberation
Electron Scanning Microscopy
Spectrum Analysis
Gels
Air

Keywords

  • carboxymethylcellulose
  • drug dissolution
  • release mechanism
  • films
  • freeze-dried wafers
  • paracetamol
  • lyophilized nasal insert
  • delivery systems
  • hpmc
  • dissolution
  • ibuprofen
  • profiles
  • matrices
  • tablets

Cite this

@article{b2c6d84e9e964e21b2cdf0e14c6f7600,
title = "In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug",
abstract = "Drug dissolution and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of drug release from the two systems. The formulations were prepared by freeze-drying (wafers) or drying in air (films), the hydrated gel of the polymer containing paracetamol as a model soluble drug. Scanning electron microscopy (SEM) was used to examine differences between the physical structure of the wafers and films. Dissolution studies were performed using an exchange cell and drug release was measured by UV spectroscopy at 242 nm. The effects of drug loading, polymer content and amount of glycerol (films) on the release characteristics of paracetamol were investigated. The release profiles of paracetamol from the wafers and films were also compared. A digital camera was used to observe the times to complete hydration and dissolution of the wafers containing different amounts of CMC and how that impacts on drug release rates. Both formulations showed sustained type drug release that was modelled by the Korsmeyer-Peppas equation. Changes in the concentration of drug and glycerol (films) did not significantly alter the rate of drug release while increasing polymer content significantly decreased the rate of drug release from both formulations. The results show that the rate of paracetamol release was faster from the wafers than the corresponding films due to differences in their physical structures. The wafers which formed a porous network, hydrated faster than the more dense and continuous, (non-porous) sheet-like structure of the films.",
keywords = "carboxymethylcellulose, drug dissolution, release mechanism, films, freeze-dried wafers, paracetamol, lyophilized nasal insert, delivery systems, hpmc, dissolution, ibuprofen, profiles, matrices, tablets",
author = "J.S. Boateng and K.H. Matthews and A.D. Auffret and M.J. Humphrey and H.N.E. Stevens and G.M. Eccleston",
year = "2009",
month = "8",
day = "13",
doi = "10.1016/j.ijpharm.2009.05.038",
language = "English",
volume = "378",
pages = "66--72",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
number = "1-2",

}

In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug. / Boateng, J.S.; Matthews, K.H.; Auffret, A.D.; Humphrey, M.J.; Stevens, H.N.E.; Eccleston, G.M.

In: International Journal of Pharmaceutics, Vol. 378, No. 1-2, 13.08.2009, p. 66-72.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug

AU - Boateng, J.S.

AU - Matthews, K.H.

AU - Auffret, A.D.

AU - Humphrey, M.J.

AU - Stevens, H.N.E.

AU - Eccleston, G.M.

PY - 2009/8/13

Y1 - 2009/8/13

N2 - Drug dissolution and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of drug release from the two systems. The formulations were prepared by freeze-drying (wafers) or drying in air (films), the hydrated gel of the polymer containing paracetamol as a model soluble drug. Scanning electron microscopy (SEM) was used to examine differences between the physical structure of the wafers and films. Dissolution studies were performed using an exchange cell and drug release was measured by UV spectroscopy at 242 nm. The effects of drug loading, polymer content and amount of glycerol (films) on the release characteristics of paracetamol were investigated. The release profiles of paracetamol from the wafers and films were also compared. A digital camera was used to observe the times to complete hydration and dissolution of the wafers containing different amounts of CMC and how that impacts on drug release rates. Both formulations showed sustained type drug release that was modelled by the Korsmeyer-Peppas equation. Changes in the concentration of drug and glycerol (films) did not significantly alter the rate of drug release while increasing polymer content significantly decreased the rate of drug release from both formulations. The results show that the rate of paracetamol release was faster from the wafers than the corresponding films due to differences in their physical structures. The wafers which formed a porous network, hydrated faster than the more dense and continuous, (non-porous) sheet-like structure of the films.

AB - Drug dissolution and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of drug release from the two systems. The formulations were prepared by freeze-drying (wafers) or drying in air (films), the hydrated gel of the polymer containing paracetamol as a model soluble drug. Scanning electron microscopy (SEM) was used to examine differences between the physical structure of the wafers and films. Dissolution studies were performed using an exchange cell and drug release was measured by UV spectroscopy at 242 nm. The effects of drug loading, polymer content and amount of glycerol (films) on the release characteristics of paracetamol were investigated. The release profiles of paracetamol from the wafers and films were also compared. A digital camera was used to observe the times to complete hydration and dissolution of the wafers containing different amounts of CMC and how that impacts on drug release rates. Both formulations showed sustained type drug release that was modelled by the Korsmeyer-Peppas equation. Changes in the concentration of drug and glycerol (films) did not significantly alter the rate of drug release while increasing polymer content significantly decreased the rate of drug release from both formulations. The results show that the rate of paracetamol release was faster from the wafers than the corresponding films due to differences in their physical structures. The wafers which formed a porous network, hydrated faster than the more dense and continuous, (non-porous) sheet-like structure of the films.

KW - carboxymethylcellulose

KW - drug dissolution

KW - release mechanism

KW - films

KW - freeze-dried wafers

KW - paracetamol

KW - lyophilized nasal insert

KW - delivery systems

KW - hpmc

KW - dissolution

KW - ibuprofen

KW - profiles

KW - matrices

KW - tablets

U2 - 10.1016/j.ijpharm.2009.05.038

DO - 10.1016/j.ijpharm.2009.05.038

M3 - Article

VL - 378

SP - 66

EP - 72

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -