In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture

Sean McGinty; Lauren Hyndman; Nigel Mottram; Sean McKee; Steven Webb

In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture

Sean McGinty, Lauren Hyndman, Nigel Mottram, Sean McKee, Steven Webb

Mathematics And Statistics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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Abstract

We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.

Original language	English
Title of host publication	CMBE17
Subtitle of host publication	5th International Conference on Computational & Mathematical Biomedical Engineering
Editors	Perumal Nithiarasu, Anne M. Robertson
Place of Publication	Swansea
Pages	1174-1177
Number of pages	4
Publication status	Published - 10 Apr 2017
Event	5th International Conference on Computational and Mathematical Biomedical Engineering - Pittsburgh, Pittsburgh, United States Duration: 10 Apr 2017 → 12 Apr 2017

Conference

Conference	5th International Conference on Computational and Mathematical Biomedical Engineering
Abbreviated title	CMBE 2017
Country/Territory	United States
City	Pittsburgh
Period	10/04/17 → 12/04/17

Keywords

cell culture systems
bioreactors
fluid dynamics
drug toxicity testing

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McGinty-etal-CMBE2017-In-silico-characterisation-of-the-Kirkstall-QV900-in-vitro-systemAccepted author manuscript, 396 KB

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title = "In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture",

abstract = "We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.",

keywords = "cell culture systems, bioreactors, fluid dynamics, drug toxicity testing",

author = "Sean McGinty and Lauren Hyndman and Nigel Mottram and Sean McKee and Steven Webb",

year = "2017",

month = apr,

day = "10",

language = "English",

isbn = "9780956291448",

pages = "1174--1177",

editor = "Perumal Nithiarasu and Robertson, {Anne M.}",

booktitle = "CMBE17",

note = "5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE 2017 ; Conference date: 10-04-2017 Through 12-04-2017",

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McGinty, S, Hyndman, L, Mottram, N , McKee, S & Webb, S 2017, In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture. in P Nithiarasu & AM Robertson (eds), CMBE17: 5th International Conference on Computational & Mathematical Biomedical Engineering. Swansea, pp. 1174-1177, 5th International Conference on Computational and Mathematical Biomedical Engineering, Pittsburgh, United States, 10/04/17.

In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture. / McGinty, Sean; Hyndman, Lauren; Mottram, Nigel et al.
CMBE17: 5th International Conference on Computational & Mathematical Biomedical Engineering. ed. / Perumal Nithiarasu; Anne M. Robertson. Swansea, 2017. p. 1174-1177.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

TY - GEN

T1 - In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture

AU - McGinty, Sean

AU - Hyndman, Lauren

AU - Mottram, Nigel

AU - McKee, Sean

AU - Webb, Steven

PY - 2017/4/10

Y1 - 2017/4/10

N2 - We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.

AB - We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.

KW - cell culture systems

KW - bioreactors

KW - fluid dynamics

KW - drug toxicity testing

UR - http://www.compbiomed.net/2017/cmbe-proceedings.htm

UR - http://eprints.gla.ac.uk/140078/

M3 - Conference contribution book

SN - 9780956291448

SP - 1174

EP - 1177

BT - CMBE17

A2 - Nithiarasu, Perumal

A2 - Robertson, Anne M.

CY - Swansea

T2 - 5th International Conference on Computational and Mathematical Biomedical Engineering

Y2 - 10 April 2017 through 12 April 2017

ER -

In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture

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