In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture

Sean McGinty, Lauren Hyndman, Nigel Mottram, Sean McKee, Steven Webb

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Abstract

We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.
Original languageEnglish
Title of host publicationCMBE17
Subtitle of host publication5th International Conference on Computational & Mathematical Biomedical Engineering
EditorsPerumal Nithiarasu, Anne M. Robertson
Place of PublicationSwansea
Pages1174-1177
Number of pages4
Publication statusPublished - 10 Apr 2017
Event5th International Conference on Computational and Mathematical Biomedical Engineering - Pittsburgh, Pittsburgh, United States
Duration: 10 Apr 201712 Apr 2017

Conference

Conference5th International Conference on Computational and Mathematical Biomedical Engineering
Abbreviated titleCMBE 2017
CountryUnited States
CityPittsburgh
Period10/04/1712/04/17

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Keywords

  • cell culture systems
  • bioreactors
  • fluid dynamics
  • drug toxicity testing

Cite this

McGinty, S., Hyndman, L., Mottram, N., McKee, S., & Webb, S. (2017). In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture. In P. Nithiarasu, & A. M. Robertson (Eds.), CMBE17: 5th International Conference on Computational & Mathematical Biomedical Engineering (pp. 1174-1177). Swansea.