We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.
|Title of host publication||CMBE17|
|Subtitle of host publication||5th International Conference on Computational & Mathematical Biomedical Engineering|
|Editors||Perumal Nithiarasu, Anne M. Robertson|
|Place of Publication||Swansea|
|Number of pages||4|
|Publication status||Published - 10 Apr 2017|
|Event||5th International Conference on Computational and Mathematical Biomedical Engineering - Pittsburgh, Pittsburgh, United States|
Duration: 10 Apr 2017 → 12 Apr 2017
|Conference||5th International Conference on Computational and Mathematical Biomedical Engineering|
|Abbreviated title||CMBE 2017|
|Period||10/04/17 → 12/04/17|
- cell culture systems
- fluid dynamics
- drug toxicity testing
McGinty, S., Hyndman, L., Mottram, N., McKee, S., & Webb, S. (2017). In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture. In P. Nithiarasu, & A. M. Robertson (Eds.), CMBE17: 5th International Conference on Computational & Mathematical Biomedical Engineering (pp. 1174-1177). Swansea.