In-line quality control of moving objects by means of spectral-domain OCT

Daniel Markl, Günther Hannesschläger, Andreas Buchsbaum, Stephan Sacher, Johannes G. Khinast, Michael Leitner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In-line quality control of intermediate and final products is essential in various industries. This may imply determining the thickness of a foil or evaluating the homogeneity of coating applied to a pharmaceutical tablet. Such a qualitative and quantitative monitoring in a depth-resolved manner can be accomplished using optical coherence tomography (OCT). In-line quality control based on OCT requires additional consideration of motion effects for the system design as well as for data interpretation. This study focuses on transverse motion effects that can arise in spectral-domain (SD-) OCT systems. The impact of a transverse movement is analyzed for a constant relative speed difference up to 0.7 m/s between sample and sensor head. In particular, transverse motion is affecting OCT system properties such as the beam displacement (distance between adjacent A-scans) and transverse resolution. These properties were evaluated theoretically and experimentally for OCT images of a resolution target and pharmaceutical film-coated tablets. Both theoretical and experimental analyses highlight the shift of the transverse resolution limiting factor from the optics to the beam displacement above a relative speed difference between sensor head and sample of 0.42 m/s (for the presented SD-OCT setup). Speeds above 0.4 m/s are often demanded when monitoring industrial processes, such as a coating process when producing film-coated tablets. This emphasizes the importance of a fast data acquisition when using OCT as in-line quality control tool.

LanguageEnglish
Pages1-10
Number of pages10
JournalOptics and Lasers in Engineering
Volume59
Early online date14 Mar 2014
DOIs
Publication statusPublished - 31 Aug 2014

Fingerprint

Optical tomography
quality control
Quality control
tomography
tablets
Tablets
Drug products
Coatings
Monitoring
sensors
Sensors
Optical resolving power
systems engineering
Pharmaceutical Preparations
Metal foil
data acquisition
homogeneity
coating
foils
Optics

Keywords

  • in-line quality control
  • motion effects
  • non-destructive testing
  • optical coherence tomography
  • pharmaceutical film-coated tablets

Cite this

Markl, Daniel ; Hannesschläger, Günther ; Buchsbaum, Andreas ; Sacher, Stephan ; Khinast, Johannes G. ; Leitner, Michael. / In-line quality control of moving objects by means of spectral-domain OCT. In: Optics and Lasers in Engineering. 2014 ; Vol. 59. pp. 1-10.
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In-line quality control of moving objects by means of spectral-domain OCT. / Markl, Daniel; Hannesschläger, Günther; Buchsbaum, Andreas; Sacher, Stephan; Khinast, Johannes G.; Leitner, Michael.

In: Optics and Lasers in Engineering, Vol. 59, 31.08.2014, p. 1-10.

Research output: Contribution to journalArticle

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