In-line monitoring of particle size and shape from image-based measurements

Research output: Contribution to conferencePoster

Abstract

Within the pharmaceutical industry, particle size and shape distributions are crucial properties of crystalline particles produced in crystallisation processes. They determine the success or otherwise of processes such as granulation, suspension treatment and drying, all involved in the manufacture of the final pharmaceutical product. Some properties of the final pharmaceutical product such as dissolution behaviour are also influenced by the particle size and shape distribution of its ingredients. Therefore, crystallisation processes need to be controlled in order to produce particles with the desired attributes (size and shape). This in turn requires an accurate characterisation of the particle attributes during the crystallisation processes. Traditionally, particle size and shape are determined by means of off-line measurements. However, these techniques only provide information on the final state of the process and involve intermediate processing steps (e.g. sampling, dissolution, drying) that can alter the properties of the particles before the measurement. In recent years, a range of in-line techniques has been developed to obtain in-situ and real-time information on the state of the process in a non-disruptive manner.

Conference

ConferenceISIC20
Abbreviated titleISIC
CountryIreland
CityDublin
Period3/09/176/09/17
Internet address

Fingerprint

Drug products
Crystallization
Particle size
Monitoring
Drying
Dissolution
Granulation
Sampling
Crystalline materials
Processing
Industry

Keywords

  • particle size
  • particle shape
  • image based measurements

Cite this

@conference{681680bae6984498b80e78ca8b52166b,
title = "In-line monitoring of particle size and shape from image-based measurements",
abstract = "Within the pharmaceutical industry, particle size and shape distributions are crucial properties of crystalline particles produced in crystallisation processes. They determine the success or otherwise of processes such as granulation, suspension treatment and drying, all involved in the manufacture of the final pharmaceutical product. Some properties of the final pharmaceutical product such as dissolution behaviour are also influenced by the particle size and shape distribution of its ingredients. Therefore, crystallisation processes need to be controlled in order to produce particles with the desired attributes (size and shape). This in turn requires an accurate characterisation of the particle attributes during the crystallisation processes. Traditionally, particle size and shape are determined by means of off-line measurements. However, these techniques only provide information on the final state of the process and involve intermediate processing steps (e.g. sampling, dissolution, drying) that can alter the properties of the particles before the measurement. In recent years, a range of in-line techniques has been developed to obtain in-situ and real-time information on the state of the process in a non-disruptive manner.",
keywords = "particle size, particle shape, image based measurements",
author = "J. Cardona and C. Ferreira and J. McGinty and A. Hamilton and O.S. Agimelen and A. Cleary and Y.C. Chen and J. Sefcik and C. Michie and R. Atkinson and I. Andonovic and C. Tachtatzis",
year = "2017",
month = "9",
day = "3",
language = "English",
note = "ISIC20 : International Symposium on Industrial Crystallization, ISIC ; Conference date: 03-09-2017 Through 06-09-2017",
url = "http://isic20.com/programme/, http://isic20.com/programme/",

}

TY - CONF

T1 - In-line monitoring of particle size and shape from image-based measurements

AU - Cardona, J.

AU - Ferreira, C.

AU - McGinty, J.

AU - Hamilton, A.

AU - Agimelen, O.S.

AU - Cleary, A.

AU - Chen, Y.C.

AU - Sefcik, J.

AU - Michie, C.

AU - Atkinson, R.

AU - Andonovic, I.

AU - Tachtatzis, C.

PY - 2017/9/3

Y1 - 2017/9/3

N2 - Within the pharmaceutical industry, particle size and shape distributions are crucial properties of crystalline particles produced in crystallisation processes. They determine the success or otherwise of processes such as granulation, suspension treatment and drying, all involved in the manufacture of the final pharmaceutical product. Some properties of the final pharmaceutical product such as dissolution behaviour are also influenced by the particle size and shape distribution of its ingredients. Therefore, crystallisation processes need to be controlled in order to produce particles with the desired attributes (size and shape). This in turn requires an accurate characterisation of the particle attributes during the crystallisation processes. Traditionally, particle size and shape are determined by means of off-line measurements. However, these techniques only provide information on the final state of the process and involve intermediate processing steps (e.g. sampling, dissolution, drying) that can alter the properties of the particles before the measurement. In recent years, a range of in-line techniques has been developed to obtain in-situ and real-time information on the state of the process in a non-disruptive manner.

AB - Within the pharmaceutical industry, particle size and shape distributions are crucial properties of crystalline particles produced in crystallisation processes. They determine the success or otherwise of processes such as granulation, suspension treatment and drying, all involved in the manufacture of the final pharmaceutical product. Some properties of the final pharmaceutical product such as dissolution behaviour are also influenced by the particle size and shape distribution of its ingredients. Therefore, crystallisation processes need to be controlled in order to produce particles with the desired attributes (size and shape). This in turn requires an accurate characterisation of the particle attributes during the crystallisation processes. Traditionally, particle size and shape are determined by means of off-line measurements. However, these techniques only provide information on the final state of the process and involve intermediate processing steps (e.g. sampling, dissolution, drying) that can alter the properties of the particles before the measurement. In recent years, a range of in-line techniques has been developed to obtain in-situ and real-time information on the state of the process in a non-disruptive manner.

KW - particle size

KW - particle shape

KW - image based measurements

UR - http://isic20.com/

M3 - Poster

ER -