Direct compaction tabletting, a widely used secondary downstream processing operation, has recently received significant research attention. Experimental data can be used to fit model parameters for the prediction of single-component tablet thickness and hardness with good agreement, and this has been done for two components (Avicel® PH-101 and Pharmatose® 50M). These pure component parameters have then been used to predict multicomponent tablet properties, with the use of novel modified parameter averaging calculations improving predictions. Furthermore, a relation has been developed to estimate the required gap between tablet press punch faces for multicomponent tablets based on the gaps required for pure components; a quick and efficient way to estimate the necessary equipment settings to generate the desired compaction forces is a useful tool.
|Title of host publication||29th European Symposium on Computer Aided Chemical Engineering|
|Number of pages||6|
|Publication status||Published - 25 Jul 2019|
|Event||29th European Symposium on Computer Aided Process Engineering - Evoluon, Eindhoven, Netherlands|
Duration: 16 Jun 2019 → 19 Jun 2019
Conference number: 29
|Name||Computer Aided Chemical Engineering|
|Conference||29th European Symposium on Computer Aided Process Engineering|
|Period||16/06/19 → 19/06/19|
- direct compaction
- tablet prediction
- continuous pharmaceutical manufacturing
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- Strathclyde Institute Of Pharmacy And Biomedical Sciences - Senior Lecturer