Improving platinum(II)-based anticancer drug delivery using cucurbit[n]urils

N.J. Wheate

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Despite the synthesis of hundreds of new platinum(II) and platinum(IV)-based complexes each year as potential anticancer drugs, only three have received world-wide approval: cisplatin, carboplatin and oxaliplatin. The next big advance in platinum-based chemotherapy is not likely to come from the development of new drugs, but from the controlled and targeted delivery of already approved drugs or those in late stage clinical trials. Encapsulation of platinum drugs inside macromolecules has already demonstrated promise, and encapsulation within cucurbit[n]urils has shown particular potential. Partial or full encapsulation within cucurbit[n]urils provides steric hindrance to drug degradation by peptides and proteins, and the use of different sized cucurbit[n]urils allows for the tuning of drug release rates, cytotoxicity and toxicity.
Original languageEnglish
Pages (from-to)2060-2066
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume102
Issue number12
DOIs
Publication statusPublished - 2008

Keywords

  • Platinum
  • Cucurbituril
  • Cancer
  • Drug delivery
  • cytotoxicity
  • toxicity
  • cisplatin
  • oxaliplatin
  • BBR3464
  • BBR3571

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