Improvements in alzheimer's disease diagnosis using principle components analysis (PCA) in combination with raman spectroscopy

J.K.J. Archer, C.D. Sudworth, R.A. Black, Rachel Williams, Thien How, Nicholas Stone, David Mann

    Research output: Contribution to journalArticle

    Abstract

    The use of optical coherence tomography (OCT) as a monitoring tool in the growth of human fibroblasts cells in collagen-based constructs is investigated. Rat-tail tendon type-1 collagen based gels mixed with human fibroblasts were prepared and incubated. Fixed samples were then imaged using OCT, and subsequently cross-sectioned and analysed microscopically. The concentration of cells in samples under different contraction dynamics was investigated using analysis of the OCT images. Results show clear differences in scattering intensity as a consequence of cell concentration in both OCT images and micrographs.
    Original languageEnglish
    Pages (from-to)662810
    JournalProceedings of SPIE the International Society for Optical Engineering
    Volume6628
    DOIs
    Publication statusPublished - Jun 2007

    Keywords

    • alzheimer's disease
    • diagnosis
    • principle components analysis
    • raman spectroscopy

    Fingerprint Dive into the research topics of 'Improvements in alzheimer's disease diagnosis using principle components analysis (PCA) in combination with raman spectroscopy'. Together they form a unique fingerprint.

  • Cite this