Improved biotransformations on charged PEGA supports

A Basso, L De Martin, L Gardossi, G Margetts, I Brazendale, A Y Bosma, R V Ulijn, S L Flitsch

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.

LanguageEnglish
Pages1296-1297
Number of pages2
JournalChemical Communications
Issue number11
Early online date7 May 2003
DOIs
Publication statusPublished - 2003

Fingerprint

amidase
Penicillin G
Swelling
Enzymes
Resins
Biotransformation
poly(acryloyl-bis(aminopropyl)polyethylene glycol)

Keywords

  • biotransformations
  • charged PEGA supports
  • swelling properties
  • aqueous media
  • neutral PEGA

Cite this

Basso, A., De Martin, L., Gardossi, L., Margetts, G., Brazendale, I., Bosma, A. Y., ... Flitsch, S. L. (2003). Improved biotransformations on charged PEGA supports. Chemical Communications, (11), 1296-1297. https://doi.org/10.1039/b301680c
Basso, A ; De Martin, L ; Gardossi, L ; Margetts, G ; Brazendale, I ; Bosma, A Y ; Ulijn, R V ; Flitsch, S L . / Improved biotransformations on charged PEGA supports. In: Chemical Communications. 2003 ; No. 11. pp. 1296-1297.
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Basso, A, De Martin, L, Gardossi, L, Margetts, G, Brazendale, I, Bosma, AY, Ulijn, RV & Flitsch, SL 2003, 'Improved biotransformations on charged PEGA supports' Chemical Communications, no. 11, pp. 1296-1297. https://doi.org/10.1039/b301680c

Improved biotransformations on charged PEGA supports. / Basso, A ; De Martin, L ; Gardossi, L ; Margetts, G ; Brazendale, I ; Bosma, A Y ; Ulijn, R V ; Flitsch, S L .

In: Chemical Communications, No. 11, 2003, p. 1296-1297.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Improved biotransformations on charged PEGA supports

AU - Basso, A

AU - De Martin, L

AU - Gardossi, L

AU - Margetts, G

AU - Brazendale, I

AU - Bosma, A Y

AU - Ulijn, R V

AU - Flitsch, S L

PY - 2003

Y1 - 2003

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AB - PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.

KW - biotransformations

KW - charged PEGA supports

KW - swelling properties

KW - aqueous media

KW - neutral PEGA

U2 - 10.1039/b301680c

DO - 10.1039/b301680c

M3 - Article

SP - 1296

EP - 1297

JO - Chemical Communications

T2 - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 11

ER -

Basso A, De Martin L, Gardossi L, Margetts G, Brazendale I, Bosma AY et al. Improved biotransformations on charged PEGA supports. Chemical Communications. 2003;(11):1296-1297. https://doi.org/10.1039/b301680c