Improved biotransformations on charged PEGA supports

A  Basso; L  De Martin; L  Gardossi; G  Margetts; I  Brazendale; A Y  Bosma; R V  Ulijn; S L  Flitsch

doi:10.1039/b301680c

Improved biotransformations on charged PEGA supports

A Basso, L De Martin, L Gardossi, G Margetts, I Brazendale, A Y Bosma, R V Ulijn, S L Flitsch

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.

Original language	English
Pages (from-to)	1296-1297
Number of pages	2
Journal	Chemical Communications
Issue number	11
Early online date	7 May 2003
DOIs	https://doi.org/10.1039/b301680c
Publication status	Published - 2003

Keywords

biotransformations
charged PEGA supports
swelling properties
aqueous media
neutral PEGA

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10.1039/b301680c

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title = "Improved biotransformations on charged PEGA supports",

abstract = "PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.",

keywords = "biotransformations, charged PEGA supports, swelling properties, aqueous media, neutral PEGA",

author = "A Basso and {De Martin}, L and L Gardossi and G Margetts and I Brazendale and Bosma, {A Y} and Ulijn, {R V} and Flitsch, {S L}",

year = "2003",

doi = "10.1039/b301680c",

language = "English",

pages = "1296--1297",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Improved biotransformations on charged PEGA supports

AU - Basso, A

AU - De Martin, L

AU - Gardossi, L

AU - Margetts, G

AU - Brazendale, I

AU - Bosma, A Y

AU - Ulijn, R V

AU - Flitsch, S L

PY - 2003

Y1 - 2003

N2 - PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.

AB - PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.

KW - biotransformations

KW - charged PEGA supports

KW - swelling properties

KW - aqueous media

KW - neutral PEGA

U2 - 10.1039/b301680c

DO - 10.1039/b301680c

M3 - Article

SN - 1359-7345

SP - 1296

EP - 1297

JO - Chemical Communications

JF - Chemical Communications

IS - 11

ER -

Improved biotransformations on charged PEGA supports

Abstract

Keywords

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