Importance of nanoparticle size in colorimetric and SERS-based multimodal trace detection of Ni(II) ions with functional gold nanoparticles

Zeljka Krpetic, Luca Guerrini, Iain A. Larmour, John Reglinski, Karen Faulds, Duncan Graham

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Colorimetric detection of analytes using gold nanoparticles along with surface-enhanced Raman spectroscopy (SERS) are areas of intense research activity since they both offer sensing of very low concentrations of target species. Multimodal detection promotes the simultaneous detection of a sample by a combination of different techniques; consequently, surface chemistry design in the development of multimodal nanosensors is important for rapid and sensitive evaluation of the analytes by diverse analytical methods. Herein it is shown that nanoparticle size plays an important role in the design of functional nanoparticles for colorimetric and SERS-based sensing applications, allowing controlled nanoparticle assembly and tunable sensor response. The design and preparation of robust nanoparticle systems and their assembly is reported for trace detection of Ni(II) ions as a model system in an aqueous solution. The combination of covalently attached nitrilotriacetic acid moieties along with the L-carnosine dipeptide on the nanoparticle surface represents a highly sensitive platform for rapid and selective detection of Ni(II) ions. This systematic study demonstrates that significantly lower detection limits can be achieved by finely tuning the assembly of gold nanoparticles of different core sizes. The results clearly demonstrate the feasibility and usefulness of a multimodal approach.

LanguageEnglish
Pages707–714
Number of pages8
JournalSmall
Volume8
Issue number5
Early online date5 Jan 2012
DOIs
Publication statusPublished - 12 Mar 2012

Fingerprint

Raman Spectrum Analysis
Gold
Nanoparticles
Raman spectroscopy
Ions
Nitrilotriacetic Acid
Carnosine
Nanosensors
Dipeptides
Surface chemistry
Limit of Detection
Tuning
Acids
Sensors
Research

Keywords

  • gold nanoparticles
  • colorimetric sensing
  • SERS
  • nickel
  • multimodal detection

Cite this

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title = "Importance of nanoparticle size in colorimetric and SERS-based multimodal trace detection of Ni(II) ions with functional gold nanoparticles",
abstract = "Colorimetric detection of analytes using gold nanoparticles along with surface-enhanced Raman spectroscopy (SERS) are areas of intense research activity since they both offer sensing of very low concentrations of target species. Multimodal detection promotes the simultaneous detection of a sample by a combination of different techniques; consequently, surface chemistry design in the development of multimodal nanosensors is important for rapid and sensitive evaluation of the analytes by diverse analytical methods. Herein it is shown that nanoparticle size plays an important role in the design of functional nanoparticles for colorimetric and SERS-based sensing applications, allowing controlled nanoparticle assembly and tunable sensor response. The design and preparation of robust nanoparticle systems and their assembly is reported for trace detection of Ni(II) ions as a model system in an aqueous solution. The combination of covalently attached nitrilotriacetic acid moieties along with the L-carnosine dipeptide on the nanoparticle surface represents a highly sensitive platform for rapid and selective detection of Ni(II) ions. This systematic study demonstrates that significantly lower detection limits can be achieved by finely tuning the assembly of gold nanoparticles of different core sizes. The results clearly demonstrate the feasibility and usefulness of a multimodal approach.",
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Importance of nanoparticle size in colorimetric and SERS-based multimodal trace detection of Ni(II) ions with functional gold nanoparticles. / Krpetic, Zeljka; Guerrini, Luca; Larmour, Iain A.; Reglinski, John; Faulds, Karen; Graham, Duncan.

In: Small, Vol. 8, No. 5, 12.03.2012, p. 707–714.

Research output: Contribution to journalArticle

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